Search
Do stress hormones influence choice? A systematic review of pharmacological interventions on the HPA axis and/or SAM system
Abstract
The hypothalamus–pituitary–adrenal axis (HPA axis) and the sympathetic–adrenal–medullary system (SAM system), two neuroendocrine systems associated with the stress response, have often been implicated to modulate decision-making in various domains. This systematic review summarizes the scientific evidence on the effects of pharmacological HPA axis and SAM system modulation on decision-making. We found 6375 references, of which 17 studies fulfilled our inclusion criteria. We quantified the risk of bias in our results with respect to missing outcome data, measurements, and selection of the reported results. The included studies administered hydrocortisone, fludrocortisone (HPA axis stimulants), yohimbine, reboxetine (SAM system stimulants), and/or propranolol (SAM system inhibitor). Integrating the evidence, we found that SAM system stimulation had no impact on risk aversion, loss aversion or intertemporal choice, while SAM system inhibition showed a tentative reduction in sensitivity to losses. HPA axis stimulation had no effect on loss aversion or reward anticipation but likely a time-dependent effect on decision under risk. Lastly, combined stimulation of both systems exhibited inconsistent results that could be explained by dose differences (loss aversion) and sex differences (risk aversion). Future research should address time-, dose-, and sex-dependencies of pharmacological effects on decision-making.
Citations
-
0
CrossRef
-
0
Web of Science
-
0
Scopus
Authors (7)
-
Alexander Jorge Rios-Florez
-
Fabio Alexis Rincon Uribe
-
Rafael Rodrigues Lima
-
Tobias Kalenscher
-
Amauri Gouveia Jr
-
Felix Jan Nitsch
Cite as
Full text
full text is not available in portal
Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
Social Cognitive and Affective Neuroscience
no. 19,
ISSN: 1749-5016 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Sarmiento Rivera L., Rios-Florez A. J., Rincon Uribe F. A., Rodrigues Lima R., Kalenscher T., Gouveia Jr A., Nitsch F. J.: Do stress hormones influence choice? A systematic review of pharmacological interventions on the HPA axis and/or SAM system// Social Cognitive and Affective Neuroscience -,iss. 1 (2024),
- DOI:
- Digital Object Identifier (open in new tab) 10.1093/scan/nsae069
- Sources of funding:
- Verified by:
- Gdańsk University of Technology
seen 5 times
Recommended for you
Mechanism of Binding of Antifungal Antibiotic Amphotericin B to Lipid Membranes: An Insight from Combined Single-Membrane Imaging, Microspectroscopy, and Molecular Dynamics
- E. Grela,
- M. Wieczór,
- R. Luchowski
- + 7 authors