Evidence for consolidation of neuronal assemblies after seizures in humans - Publication - Bridge of Knowledge

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Evidence for consolidation of neuronal assemblies after seizures in humans

Abstract

The establishment of memories involves reactivation of waking neuronal activity patterns and strengthening of associated neural circuits during slow-wave sleep (SWS), a process known as "cellular consolidation" (Dudai and Morris, 2013). Reactivation of neural activity patterns during waking behaviors that occurs on a timescale of seconds to minutes is thought to constitute memory recall (O'Keefe and Nadel, 1978), whereas consolidation of memory traces may be revealed and served by correlated firing (reactivation) that appears during sleep under conditions suitable for synaptic modification (Buhry et al., 2011). Although reactivation has been observed in human neuronal recordings (Gelbard-Sagiv et al., 2008; Miller et al., 2013), reactivation during sleep has not, likely because data are difficult to obtain and the effect is subtle. Seizures, however, provide intense and synchronous, yet sparse activation (Bower et al., 2012) that could produce a stronger consolidation effect if seizures activate learning-related mechanisms similar to those activated by learned tasks. Continuous wide-bandwidth recordings from patients undergoing intracranial monitoring for drug-resistant epilepsy revealed reactivation of seizure-related neuronal activity during subsequent SWS, but not wakefulness. Those neuronal assemblies that were most strongly activated during seizures showed the largest correlation changes, suggesting that consolidation selectively strengthened neuronal circuits activated by seizures. These results suggest that seizures "hijack" physiological learning mechanisms and also suggest a novel epilepsy therapy targeting neuronal dynamics during post-seizure sleep.

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Authors (12)

  • Photo of  Mark R. Bower

    Mark R. Bower

    • Department of Neurology
  • Photo of  Matt Stead

    Matt Stead

    • Department of Neurology
  • Photo of  Regina S. Bower

    Regina S. Bower

    • Department of Neurologic Surgery
  • Photo of dr Michał Tomasz Kucewicz

    Michał Tomasz Kucewicz dr

    • Department of Neurology
  • Photo of  Vladimir Sulc

    Vladimir Sulc

    • Department of Neurology
  • Photo of  Jan Cymbalnik

    Jan Cymbalnik

    • Department of Neurology
  • Photo of  Benjamin H. Brinkmann

    Benjamin H. Brinkmann

    • Department of Neurology
  • Photo of  Vincent Vasoli

    Vincent Vasoli

    • Department of Neurology
  • Photo of  Erik K. ST.Louis

    Erik K. ST.Louis

    • Departments of Medicine and Neurology
  • Photo of  Frederic Meyer

    Frederic Meyer

    • Department of Neurologic Surgery
  • Photo of  W. Richard Marsh

    W. Richard Marsh

    • Department of Neurologic Surgery
  • Photo of  Gregory A. Worrell

    Gregory A. Worrell

    • Department of Neurology

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DOI:
Digital Object Identifier (open in new tab) 10.1523/JNEUROSCI.3019-14.2015
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Details

Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
Journal of Neuroscience no. 35, edition 3, pages 999 - 1010,
ISSN: 0270-6474
Language:
English
Publication year:
2015
Bibliographic description:
Bower M., Stead M., Bower R., Kucewicz M., Sulc V., Cymbalnik J., Brinkmann B., Vasoli V., St.Louis E., Meyer F., Marsh W., Worrell G.: Evidence for consolidation of neuronal assemblies after seizures in humans// Journal of Neuroscience. -Vol. 35, iss. 3 (2015), s.999-1010
DOI:
Digital Object Identifier (open in new tab) 10.1523/jneurosci.3019-14.2015
Verified by:
Gdańsk University of Technology

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