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Abstract
People often forget information because they fail to effectively encode it. Here, we test the hypothesis that targeted electrical stimulation can modulate neural encoding states and subsequent memory outcomes. Using recordings from neurosurgical epilepsy patients with intracranially implanted electrodes, we trained multivariate classifiers to discriminate spectral activity during learning that predicted remembering from forgetting, then decoded neural activity in later sessions in which we applied stimulation during learning. Stimulation increased encoding-state estimates and recall if delivered when the classifier indicated low encoding efficiency but had the reverse effect if stimulation was delivered when the classifier indicated high encoding efficiency. Higher encoding-state estimates from stimulation were associated with greater evidence of neural activity linked to contextual memory encoding. In identifying the conditions under which stimulation modulates memory, the data suggest strategies for therapeutically treating memory dysfunction.
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Authors (26)
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Youssef Ezzyat
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James E. Kragel
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John F. Burke
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Deborah F. Levy
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Anastasia Lyalenko
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Paul Wanda
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Logan O'Sullivan
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Katherine B. Hurley
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Stanislav Busygin
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Isaac Pedisich
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Michael R. Sperling
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Gregory Worrell
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Kathryn A. Davis
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Timothy H. Lucas
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Cory S. Inman
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Bradley C. Lega
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Barbara C. Jobst
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Sameer A. Sheth
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Kareem Zaghloul
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Michael J. Jutras
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Joel M. Stein
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Sandhitsu R. Das
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Richard Gorniak
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Daniel S. Rizzuto
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Michael J. Kahana
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.cub.2017.03.028
- License
- Copyright (2017 Elsevier Ltd)
Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
CURRENT BIOLOGY
no. 27,
edition 9,
pages 1251 - 1258,
ISSN: 0960-9822 - Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Ezzyat Y., Kragel J., Burke J., Levy D., Lyalenko A., Wanda P., O'sullivan L., Hurley K., Busygin S., Pedisich I., Sperling M., Worrell G., Kucewicz M., Davis K., Lucas T., Inman C., Lega B., Jobst B., Sheth S., Zaghloul K., Jutras M., Stein J., Das S., Gorniak R., Rizzuto D., Kahana M.: Direct brain stimulation modulates encoding states and memory performance in humans// CURRENT BIOLOGY. -Vol. 27, iss. 9 (2017), s.1251-1258
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.cub.2017.03.028
- Verified by:
- Gdańsk University of Technology
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