Closed-loop stimulation of temporal cortex rescues functional networks and improves memory - Publication - Bridge of Knowledge

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Closed-loop stimulation of temporal cortex rescues functional networks and improves memory

Abstract

Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation of brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation and often target the hippocampus and medial temporal lobes. Here we use a closed-loop system to monitor and decode neural activity from direct brain recordings in humans. We apply targeted stimulation to lateral temporal cortex and report that this stimulation rescues periods of poor memory encoding. This system also improves later recall, revealing that the lateral temporal cortex is a reliable target for memory enhancement. Taken together, our results suggest that such systems may provide a therapeutic approach for treating memory dysfunction.

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Authors (22)

  • Photo of  Youssef Ezzyat

    Youssef Ezzyat

    • University of Pennsylvania Department of Psychology
  • Photo of  Paul A. Wanda

    Paul A. Wanda

    • University of Pennsylvania Department of Psychology
  • Photo of  Deborah F. Levy

    Deborah F. Levy

    • University of Pennsylvania Department of Psychology
  • Photo of  Allison Kadel

    Allison Kadel

    • University of Pennsylvania Department of Psychology
  • Photo of  Ada Aka

    Ada Aka

    • University of Pennsylvania Department of Psychology
  • Photo of  Isaac Pedisich

    Isaac Pedisich

    • University of Pennsylvania Department of Psychology
  • Photo of  Michael R. Sperling

    Michael R. Sperling

    • Thomas Jefferson University Hospital Deparment of Neurology
  • Photo of  Ashwini Sharan

    Ashwini Sharan

    • Thomas Jefferson University Hospital Department of Neurosurgery
  • Photo of  Bradley C. Lega

    Bradley C. Lega

    • University of Texas Department of Neurosurgery
  • Photo of  Alexis Burks

    Alexis Burks

    • University of Texas Department of Neurosurgery
  • Photo of  Robert E. Gross

    Robert E. Gross

    • Emory University Hospital, Department of Neurosurgery
  • Photo of  Cory S. Inman

    Cory S. Inman

    • Emory University Hospital Department of Neurosurgery
  • Photo of  Barbara C. Jobst

    Barbara C. Jobst

    • Dartmouth-Hitchcock Medical Center Department of Neurology
  • Photo of  Mark A. Gorenstein

    Mark A. Gorenstein

    • Dartmouth-Hitchcock Medical Center Department of Neurology
  • Photo of  Kathryn A. Davis

    Kathryn A. Davis

    • Hospital of the University of Pennsylvania Department of Neurology
  • Photo of  Gregory A. Worrell

    Gregory A. Worrell

    • Mayo Clinic Department of Neurology
  • Photo of  Joel M. Stein

    Joel M. Stein

    • Hospital of the University of Pennsylvania Department of Radiology
  • Photo of  Richard Gorniak

    Richard Gorniak

    • Thomas Jefferson University Hospital Department of Radiology
  • Photo of  Sandhitsu R. Das

    Sandhitsu R. Das

    • Hospital of the University of Pennsylvania Department of Neurology
  • Photo of  Daniel S. Rizzuto

    Daniel S. Rizzuto

    • University of Pennsylvania Department of Psychology
  • Photo of  Michael J. Kahana

    Michael J. Kahana

    • University of Pennsylvania Department of Psychology

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Details

Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
Nature Communications no. 9, pages 1 - 8,
ISSN: 2041-1723
Language:
English
Publication year:
2018
Bibliographic description:
Ezzyat Y., Wanda P. A., Levy D. F., Kadel A., Aka A., Pedisich I., Sperling M. R., Sharan A., Lega B. C., Burks A., Gross R. E., Inman C. S., Jobst B. C., Gorenstein M. A., Davis K. A., Worrell G. A., Kucewicz M. T., Stein J. M., Gorniak R., Das S. R., Rizzuto D. S., Kahana M. J.: Closed-loop stimulation of temporal cortex rescues functional networks and improves memory// Nature Communications. -Vol. 9, (2018), s.1-8
DOI:
Digital Object Identifier (open in new tab) 10.1038/s41467-017-02753-0
Verified by:
Gdańsk University of Technology

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