Search
Abstract
Direct electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition. Despite its application in a range of brain disorders, it remains unclear how stimulation of discrete brain areas affects memory performance and the underlying electrophysiological activities. Here, we investigated the effect of direct electrical stimulation in four brain regions known to support declarative memory: hippocampus (HP), parahippocampal region (PH) neocortex, prefrontal cortex (PF), and lateral temporal cortex (TC). Intracranial EEG recordings with stimulation were collected from 22 patients during performance of verbal memory tasks. We found that high γ (62–118 Hz) activity induced by word presentation was modulated by electrical stimulation. This modulatory effect was greatest for trials with “poor” memory encoding. The high γ modulation correlated with the behavioral effect of stimulation in a given brain region: it was negative, i.e., the induced high γ activity was decreased, in the regions where stimulation decreased memory performance, and positive in the lateral TC where memory enhancement was observed. Our results suggest that the effect of electrical stimulation on high γ activity induced by word presentation may be a useful biomarker for mapping memory networks and guiding therapeutic brain stimulation.
Citations
-
4 0
CrossRef
-
0
Web of Science
-
3 4
Scopus
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1523/ENEURO.0369-17.2018
- License
-
open in new tab
Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
eNeuro
no. 5,
edition 1,
pages 1 - 14,
ISSN: 2373-2822 - Language:
- English
- Publication year:
- 2018
- DOI:
- Digital Object Identifier (open in new tab) 10.1523/eneuro.0369-17.2018
- Verified by:
- Gdańsk University of Technology
seen 122 times
Recommended for you
Closed-loop stimulation of temporal cortex rescues functional networks and improves memory
- Y. Ezzyat,
- P. A. Wanda,
- D. F. Levy
- + 19 authors
Human memory enhancement through electrical stimulation in the temporal cortex
- M. T. Kucewicz,
- B. M. Berry,
- L. R. Miller
- + 17 authors
Human verbal memory encoding is hierarchically distributed in a continuous processing stream
- M. T. Kucewicz,
- K. Saboo,
- B. M. Berry
- + 15 authors
Direct brain stimulation modulates encoding states and memory performance in humans
- Y. Ezzyat,
- J. E. Kragel,
- J. F. Burke
- + 23 authors