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Abstract
Gelatin-based films modified with sorbitol were produced from gelatin solution or gelatin/starch blends using a simple and low-cost solvent casting method, and subsequently, their physicochemical, mechanical, and biocompatibility properties were characterized. This work focused on developing and optimizing a biopolymeric blend to improve the pure biopolymers’ properties for potential biomedical applications such as wound dressing. The films were characterized in terms of morphology and transparency, mechanical, moisture and swelling properties, thermal stability, and degradation potential. Moreover, hemocompatibility, as well as cytocompatibility of prepared films, were examined. The addition of sorbitol contributed to improving mechanical properties, swelling reduction, and increasing biostability over time. The cytocompatibility of obtained films was confirmed in vitro with two different human cell lines, fibroblastic and osteoblastic, and a more favorable cellular response was received for fibroblasts. Further, in hemocompatibility studies, it was found that all films may be classified as non-hemolytic as they did not have a negative effect on the human erythrocytes. The obtained results indicate the great potential of the gelatin/starch blends modified with sorbitol as regenerative biomaterials intended for wound healing applications.
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Authors (8)
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Justyna Kozłowska dr hab.
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Joanna Skopińska-Wiśniewska dr
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Beata Kaczmarek-Szczepańska dr
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Anna Michno dr hab. n. med.
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Anna Ronowska dr hab. n. med.
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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Journal of the Mechanical Behavior of Biomedical Materials
no. 148,
ISSN: 1751-6161 - Language:
- English
- Publication year:
- 2023
- Bibliographic description:
- Kozłowska J., Skopińska-Wiśniewska J., Kaczmarek-Szczepańska B., Grabska-Zielińska S., Makurat-Kasprolewicz B., Michno A., Ronowska A., Wekwejt M.: Gelatin and gelatin/starch-based films modified with sorbitol for wound healing// Journal of the Mechanical Behavior of Biomedical Materials -Vol. 148, (2023), s.106205-
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.jmbbm.2023.106205
- Sources of funding:
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- National Science Centre (NCN, Poland) Grant No UMO-2016/21/D/ST8/01705 and Founds of Medical University of Gdansk (71-01415zd0004611/2023).
- Verified by:
- Gdańsk University of Technology
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