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Gelatin-Modified Polyurethanes for Soft Tissue Scaffold

Abstract

Recently, in the field of biomaterials, which are being designed for soft tissue scaffolding, is growing the interest of their modification with natural polymers. Synthetic polymers are often hard, not easy to process and they do not possess fine biodegradable profile. From the other hand natural polymers are biocompatible, but weak when used alone. The combination of natural and synthetic polymers gives the suitable properties for tissue engineering. Polyurethanes in our study represent the synthetic polymers, which are prepared from polyester poly(ethylene-butylene adipate) (EBO), aliphatic 1,6-hexamethylene diisocyanate (HDI) and two different chain extenders 1,4-butanediol (BDO) or 2-[2-(2-hydroxyethoxy)ethoxy]ethanol (TG). In our study we replaced expensive isocyanates like 2,6-diisocyanato methyl caproate (LDI) or 1,4-diisocyanatobutane (BDI) with cost effective HDI. The applied natural polymer was collagen derivative - gelatin. By blending in situ of these two polymers we obtained material with increased biocompatybility and biodegradability suitable for soft tissue engineering.

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DOI:
Digital Object Identifier (open in new tab) 10.1155/2013/450132
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Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
TheScientificWorldJOURNAL no. 2013, pages 1 - 12,
ISSN: 1537-744X
Language:
English
Publication year:
2013
Bibliographic description:
Kucińska-Lipka J., Gubańska I., Janik H.: Gelatin-Modified Polyurethanes for Soft Tissue Scaffold// TheScientificWorldJOURNAL. -Vol. 2013, nr. ID 450132 (2013), s.1-12
DOI:
Digital Object Identifier (open in new tab) 10.1155/2013/450132
Verified by:
Gdańsk University of Technology

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