Human subarachnoid space width oscillations in the resting state - Publication - Bridge of Knowledge

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Human subarachnoid space width oscillations in the resting state

Abstract

Abnormal cerebrospinal fluid (CSF) pulsatility has been implicated in patients suffering from various diseases, including multiple sclerosis and hypertension. CSF pulsatility results in subarachnoid space (SAS) width changes, which can be measured with near-infrared transillumination backscattering sounding (NIR-T/BSS). The aim of this study was to combine NIR-T/BSS and wavelet analysis methods to characterise the dynamics of the SAS width within a wide range of frequencies from 0.005 to 2 Hz, with low frequencies studied in detail for the first time. From recordings in the resting state, we also demonstrate the relationships between SAS width in both hemispheres of the brain, and investigate how the SAS width dynamics is related to the blood pressure (BP). These investigations also revealed influences of age and SAS correlation on the dynamics of SAS width and its similarity with the BP. Combination of NIR-T/BSS and time-frequency analysis may open up new frontiers in the understanding and diagnosis of various neurodegenerative and ageing related diseases to improve diagnostic procedures and patient prognosis.

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Authors (9)

  • Photo of  Marcin Gruszecki

    Marcin Gruszecki

    • Gdański Uniwersytet Medyczny Katedra Medycyny Nuklearnej i Informatyki Radiologicznej
  • Photo of  Gemma Lancaster

    Gemma Lancaster

    • Univ Lancaster, England Dept. Phys.
  • Photo of  Aneta Stefanovska

    Aneta Stefanovska

    • Univ Lancaster, England Dept. Phys.
  • Photo of  Patric J. Neary

    Patric J. Neary

    • Univ Regina, Canada Fac Kinesiol & Hlth Studies
  • Photo of  Ryan Dech

    Ryan Dech

    • Univ Regina, Canada Fac Kinesiol & Hlth Studies
  • Photo of  Andrzej F. Frydrychowski

    Andrzej F. Frydrychowski

    • Gdański Uniwersytet Medyczny Zakład Fizjologii Człowieka
  • Photo of  Jacek Kot

    Jacek Kot

    • Gdański Uniwersytet Medyczny Instytu Medycyny Morskiej i Tropikalnej
  • Photo of  Pawel Winklewski

    Pawel Winklewski

    • Gdański Uniwersytet Medyczny Zakład Fizjologii Człowieka

Keywords

Details

Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
Scientific Reports no. 8,
ISSN: 2045-2322
Language:
English
Publication year:
2018
Bibliographic description:
Gruszecki M., Lancaster G., Stefanovska A., Neary P. J., Dech R., Gumiński W., Frydrychowski A. F., Kot J., Winklewski P.: Human subarachnoid space width oscillations in the resting state// Scientific Reports. -Vol. 8, iss. 1 (2018), s.3057-
DOI:
Digital Object Identifier (open in new tab) 10.1038/s41598-018-21038-0
Verified by:
Gdańsk University of Technology

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