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Abstract
Background: Little is known about intracranial pressure (ICP)-cerebral haemodynamic interplay during repetitive apnoea. A recently developed method based on near-infrared transillumination/backscattering sounding (NIR-T/BSS) noninvasively measures changes in pial artery pulsation (cc-TQ) as well as subarachnoid width (sas-TQ) in humans. Method: We tested the complex response of the pial artery and subarachnoid width to apnoea using this method. The pial artery and subarachnoid width response to consecutive apnoeas lasting 30, 60 s and maximal breath-hold (91.1 ± 23.1 s) were studied in 20 healthy volunteers. The cc-TQ and sas-TQ were measured using NIR-T/BSS; cerebral blood flow velocity (CBFV), pulsatility index and resistive index were measured using Doppler ultrasound of the left internal carotid artery; heart rate (HR) and beat-to-beat SBP and DBP blood pressure were recorded using a Finometer; end-tidal CO2 (EtCO2) was measured using a medical gas analyser. Results: Apnoea evoked a multiphasic response in blood pressure, pial artery compliance and ICP. First, SBP declined, which was accompanied by an increase in cc-TQ and sas-TQ. Directly after these changes, SBP exceeded baseline values, which was followed by a decline in cc-TQ and the return of sas-TQ to baseline. During these initial changes, CBFV remained stable. Towards the end of the apnoea, BP, cc-TQ and CBFV increased, whereas pulsatility index, resistive index and sas-TQ declined. Changes in sas-TQ were linked to changes in EtCO2, HR and SBP. Conclusion: Apnoea is associated with ICP swings, closely reflecting changes in EtCO2, HR and peripheral BP. The baroreflex influences the pial artery response.
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Authors (11)
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Magdalena Wszędybył-Winklewska
- Gdański Uniwersytet Medyczny Wydział Nauk o Zdrowiu
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Jacek Wolf
- Gdański Uniwersytet Medyczny Wydział Nauk o Zdrowiu
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Ewa Świerblewska
- Gdański Uniwersytet Medyczny Wydział Nauk o Zdrowiu
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Katarzyna Kunicka
- Gdański Uniwersytet Medyczny Wydział Nauk o Zdrowiu
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Marcin Gruszecki
- Gdański Uniwersytet Medyczny Wydział Nauk o Zdrowiu
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Paweł J. Winklewski
- Gdański Uniwersytet Medyczny Wydział Nauk o Zdrowiu
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Andrzej F. Frydrychowski
- Gdański Uniwersytet Medyczny Wydział Nauk o Zdrowiu
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Leszek Bieniaszewski
- Gdański Uniwersytet Medyczny Wydział Nauk o Zdrowiu
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Krzysztof Narkiewicz
- Gdański Uniwersytet Medyczny Wydział Nauk o Zdrowiu
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Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
JOURNAL OF HYPERTENSION
no. 33,
edition 9,
pages 1811 - 1817,
ISSN: 0263-6352 - Language:
- English
- Publication year:
- 2015
- Bibliographic description:
- Wszędybył-Winklewska M., Wolf J., Świerblewska E., Kunicka K., Gruszecki M., Gumiński W., Winklewski P., Frydrychowski A., Bieniaszewski L., Narkiewicz k.: Pial artery and subarachnoid width response to apnoea in normal humans// JOURNAL OF HYPERTENSION. -Vol. 33, iss. 9 (2015), s.1811-1817
- DOI:
- Digital Object Identifier (open in new tab) 10.1097/hjh.0000000000000613
- Verified by:
- Gdańsk University of Technology
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