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Metal–Organic Frameworks (MOFs) for Cancer Therapy

Abstract

MOFs exhibit inherent extraordinary features for diverse applications ranging from catalysis, storage, and optics to chemosensory and biomedical science and technology. Several procedures including solvothermal, hydrothermal, mechanochemical, electrochemical, and ultrasound techniques have been used to synthesize MOFs with tailored features. A continued attempt has also been directed towards functionalizing MOFs via “post-synthetic modification” mainly by changing linkers (by altering the type, length, functionality, and charge of the linkers) or node components within the MOF framework. Additionally, efforts are aimed towards manipulating the size and morphology of crystallite domains in the MOFs, which are aimed at enlarging their applications window. Today’s knowledge of artificial intelligence and machine learning has opened new pathways to elaborate multiple nanoporous complex MOFs and nano-MOFs (NMOFs) for advanced theranostic, clinical, imaging, and diagnostic purposes. Successful accumulation of a photosensitizer in cancerous cells was a significant step in cancer therapy. The application of MOFs as advanced materials and systems for cancer therapy is the main scope beyond this perspective. Some challenging aspects and promising features in MOF-based cancer diagnosis and cancer therapy have also been discussed.

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DOI:
Digital Object Identifier (open in new tab) 10.3390/ma14237277
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Category:
Articles
Type:
artykuły w czasopismach
Published in:
Materials no. 14,
ISSN: 1996-1944
Language:
English
Publication year:
2021
Bibliographic description:
Saeb M., Rabiee N., Mozafari M., Verpoort F., Voskressensky L. G., Luque R.: Metal–Organic Frameworks (MOFs) for Cancer Therapy// Materials -Vol. 14,iss. 23 (2021), s.7277-
DOI:
Digital Object Identifier (open in new tab) 10.3390/ma14237277
Verified by:
Gdańsk University of Technology

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