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Modeling and MANOVA studies on toxicity and endocrine potential of packaging materials exposed to different extraction schemes
Abstract
The stability of the linings of packaging that is in contact with the goods stored has been of major concern during decades of the development of packaging materials. In this work, an attempt was undertaken to assess the applicability of using two bioassays (Microtox® and XenoScreen YES/YAS) in estimating the stability of packaging (cans, caps, multilayer material) and the impact of their degradation on the toxicity of some simulated media. The assessment of the impact of packaging storage conditions (temperature, disinfection, preservation, extracting and washing solvents) was planned and performed with i) regression modeling of the experimental effects on the ecotoxicity readings, ii) ANOVA and MANOVA estimation of the experimental conditions as significant factors affecting the toxicity results and iii) FTIR analysis of the packages. It is shown that the effects of temperature and extraction solvents could be quantitatively assessed by the agreement between all methods applied. It can be stated that temperature and acidity as well as the alcohol content in the sensitive media have the greatest impact on the toxicity of the extract and thus on the stability of the internal lining and the extractability of xenobiotics.
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Authors (8)
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Stefan Tsakovski
- University of Sofia Department of Analytical Chemistry
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Galina Yotova
- University of Sofia Department of Analytical Chemistry
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Miroslava Nedyalkova
- University of Sofia Chair of General and Inorganic Chemistry
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Vasil Simeonov prof. dr hab. inż.
- University of Sofia Department of Analytical Chemistry
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
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ENVIRONMENTAL RESEARCH
no. 165,
pages 294 - 305,
ISSN: 0013-9351 - Language:
- English
- Publication year:
- 2018
- Bibliographic description:
- Szczepańska N., Kudłak B., Tsakovski S., Yotova G., Nedyalkova M., Simeonov, V., Dołęga A., Namieśnik J.: Modeling and MANOVA studies on toxicity and endocrine potential of packaging materials exposed to different extraction schemes// ENVIRONMENTAL RESEARCH. -Vol. 165, (2018), s.294-305
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.envres.2018.05.004
- Verified by:
- Gdańsk University of Technology
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