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New conjugates of mycophenolic acid and their antiproliferative activity

Abstract

The new conjugates of mycophenolic acid (MPA) were obtained in the reaction of N6-(ω-aminoalkyl)adenosines with MPA in the presence of EDCI as a coupling reagent. New compounds 4a–h were evaluated on leukemia cell line (Jurkat) and PBMC from healthy donors. Length of the linker influenced observed activity. The compound 4b possessing 1,3-diamine spacer exhibited the most promising results and can be considered to further investigations.

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Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH no. 18, edition 11, pages 1057 - 1062,
ISSN: 1028-6020
Language:
English
Publication year:
2016
Bibliographic description:
Prejs M., Cholewiński G., Siebert A., Trzonkowski P., Dzierzbicka K.: New conjugates of mycophenolic acid and their antiproliferative activity// JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH. -Vol. 18, iss. 11 (2016), s.1057-1062
DOI:
Digital Object Identifier (open in new tab) 10.1080/10286020.2016.1184653
Verified by:
Gdańsk University of Technology

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