Abstract
High-frequency oscillations (HFO; gamma: 40-100 Hz, ripples: 100-200 Hz, and fast ripples: 250-500 Hz) have been widely studied in health and disease. These phenomena may serve as biomarkers for epileptic brain; however, a means of differentiating between pathological and normal physiological HFO is essential. We categorized task-induced physiological HFO during periods of HFO induced by a visual or motor task by measuring frequency, duration, and spectral amplitude of each event in single trial time-frequency spectra and compared them to pathological HFO similarly measured. Pathological HFO had higher mean spectral amplitude, longer mean duration, and lower mean frequency than physiological-induced HFO. In individual patients, support vector machine analysis correctly classified pathological HFO with sensitivities ranging from 70-98% and specificities >90% in all but one patient. In this patient, infrequent high-amplitude HFO were observed in the motor cortex just before movement onset in the motor task. This finding raises the possibility that in epileptic brain physiological-induced gamma can assume higher spectral amplitudes similar to those seen in pathologic HFO. This method if automated and validated could provide a step towards differentiating physiological HFO from pathological HFO and improving localization of epileptogenic brain.
Citations
-
1 8 2
CrossRef
-
0
Web of Science
-
1 6 6
Scopus
Authors (8)
Cite as
Full text
full text is not available in portal
Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
JOURNAL OF NEUROPHYSIOLOGY
no. 110,
edition 8,
pages 1958 - 1964,
ISSN: 0022-3077 - Language:
- English
- Publication year:
- 2013
- Bibliographic description:
- Matsumoto A., Brinkmann B., Stead S., Matsumoto J., Kucewicz M., Marsh W., Meyer F., Worrell G.: Pathological and physiological high-frequency oscillations in focal human epilepsy// JOURNAL OF NEUROPHYSIOLOGY. -Vol. 110, iss. 8 (2013), s.1958-1964
- DOI:
- Digital Object Identifier (open in new tab) 10.1152/jn.00341.2013
- Verified by:
- Gdańsk University of Technology
seen 137 times
Recommended for you
Interictal high-frequency oscillations in focal human epilepsy
- J. Cymbalnik,
- M. T. Kucewicz,
- G. A. Worrell
Gamma oscillations precede interictal epileptiform spikes in the seizure onset zone
- L. Ren,
- M. T. Kucewicz,
- J. Cymbalnik
- + 7 authors
Dissecting gamma frequency activities during human memory processing
- M. T. Kucewicz,
- B. M. Berry,
- V. Kremen
- + 13 authors
High frequency oscillations are associated with cognitive processing in human recognition memory
- M. T. Kucewicz,
- J. Cymbalnik,
- J. Matsumoto
- + 8 authors