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Peptide modification with thiomalonoamide moiety

Abstract

Abstract: Meldrum acid derivatives under the thermal decomposition are well known source of ketenes. Recently we investigated chemical properties of thiocarbamolyl meldrum acids. We found that 5-(α-alkylamino- α'-sulfhydryl)methylene Meldrum's acids hated in the presence of amines produce thiomalonamides. We used this reaction to the one pot synthesis of series of short peptides containing thiomalonoamide motif.

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Category:
Conference activity
Type:
publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
Title of issue:
14th International Symposium of Students and Young Mechanical Engineers :''Advances in Chemical and Mechanical Engineering". - Vol. 1/2, Gdansk, 5th-7th May 2011 strony 252 - 253
Language:
English
Publication year:
2011
Bibliographic description:
Janikowska K., Makowiec S.: Peptide modification with thiomalonoamide moiety// 14th International Symposium of Students and Young Mechanical Engineers :''Advances in Chemical and Mechanical Engineering". - Vol. 1/2, Gdansk, 5th-7th May 2011/ ed. ed. C. Fijało. - Faculty Mechanical Engineering, Chemical Faculty Gdansk University of Technology. Gdańsk: , 2011, s.252-253
Verified by:
Gdańsk University of Technology

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