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One-Step Synthesis of b-Lactams with Retro-Amide Side Chain

Abstract

Abstract: A one pot synthesis for preparation of 1,4-disubstituted-2-oxo-azetidine-3-carboxylic acid amides was developed. 5-(α-N-substituted-amino-α'-hydroxy)methylene Meldrum's acids act as a source of ketenes that react with aldimines in boiling toluene to give b-lactams with retro-amid side chain.

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Accepted or Published Version
DOI:
Digital Object Identifier (open in new tab) 10.1055/s-0030-1258966
License
Copyright (2011 Georg Thieme Verlag Stuttgart, New York)

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Details

Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
SYNTHESIS-STUTTGART pages 69 - 72,
ISSN: 0039-7881
Language:
English
Publication year:
2011
Bibliographic description:
Janikowska K., Pawelska N., Makowiec S.: One-Step Synthesis of b-Lactams with Retro-Amide Side Chain// SYNTHESIS-STUTTGART. -, nr. iss. 1 (2011), s.69-72
Verified by:
Gdańsk University of Technology

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