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Abstract
THE SUPERCRITICAL FLUID IS AN EXCELLENT CHOICE AS THE CHROMATOGRAPHIC MOBILE PHASE BECAUSE IT ALLOWS RAPID SEPARATION WITH HIGH EFFICIENCY AND APPLICATIONS INVOLVING ENANTIORESOLUTION ARE COMMON. SUPERCRITICAL FLUID CHROMATOGRAPHY (SFC) IS INCREASINGLY USED FOR ANALYTICAL, SEMI-PREPARATIVE AND PREPARATIVE PURIFICATION OF CHIRAL COMPOUNDS, INCLUDING PRODUCTION OF ENANTIOMERS THAT ARE MAINLY ENCOUNTERED DURING DRUG DEVELOPMENT. SFC CAN BE USED AS AN ALTERNATIVE TO HPLC FOR MANY DRUG SUBSTANCES, SO IT IS GAINING POPULARITY IN THE PHARMACEUTICAL INDUSTRY. THE MAIN ADVANTAGES OF SFC IN SEPARATING CHIRAL PHARMACEUTICALS ARE: HIGH SPEED, SHORT ANALYSIS TIME, LIMITED ENVIRONMENTAL IMPACT AND HIGH EFFICIENCY. THE REDUCTION IN THE USE OF ORGANIC SOLVENTS HAS COST, HEALTH, AND SAFETY BENEFITS. DUE TO THESE ADVANTAGES, SFC FULFILLS ALL THE REQUIREMENTS OF GREEN ANALYTICAL CHEMISTRY APPROACHES. IN THIS ARTICLE, WE PRESENT APPLICATION OF SFC AS A TOOL FOR CHIRAL SEPARATION OF PHARMACEUTICALS AND DRUGS OF ABUSE.
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Authors (4)
-
Calum Morrison
- School of Science Faculty of Science and Technology
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
no. 56,
pages 74 - 89,
ISSN: 0165-9936 - Language:
- English
- Publication year:
- 2014
- Bibliographic description:
- Płotka-Wasylka J., Biziuk M., Morrison C., Namieśnik J.: Pharmaceutical and forensic drug applications of chiral supercritical fluid chromatography// TRAC-TRENDS IN ANALYTICAL CHEMISTRY. -Vol. 56, (2014), s.74-89
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.trac.2013.12.012
- Verified by:
- Gdańsk University of Technology
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