Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria - Publication - Bridge of Knowledge

Your account

login

Search

Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria

Abstract

In eukaryotic cells, different organelles interact at membrane contact sites stabilized by tethers. Mitochondrial mitofusin 2 (MFN2) acts as a membrane tether that interacts with an unknown partner on the endoplasmic reticulum (ER). In this work, we identified the MFN2 splice variant ERMIT2 as the ER tethering partner of MFN2. Splicing of MFN2 produced ERMIT2 and ERMIN2, two ER-specific variants. ERMIN2 regulated ER morphology, whereas ERMIT2 localized at the ER-mitochondria interface and interacted with mitochondrial mitofusins to tether ER and mitochondria. This tethering allowed efficient mitochondrial calcium ion uptake and phospholipid transfer. Expression of ERMIT2 ameliorated the ER stress, inflammation, and fibrosis typical of liver-specific Mfn2 knockout mice. Thus, ER-specific MFN2 variants display entirely extramitochondrial MFN2 functions involved in interorganellar tethering and liver metabolic activities.

Citations

  • 1 2

    CrossRef

  • 0

    Web of Science

  • 1 0

    Scopus

Authors (19)

Cite as

Full text

full text is not available in portal

Keywords

Details

Category:
Articles
Type:
artykuły w czasopismach
Published in:
SCIENCE no. 380, pages 1 - 13,
ISSN: 0036-8075
Language:
English
Publication year:
2023
Bibliographic description:
Naón D., Hernández-Alvarez M. I., Shinjo S., Wieczór M., Ivanova S., Martins de Brito O., Quintana A., Hidalgo J., Palacín M., Aparicio P., Castellanos J., Lores L., Sebastián D., Fernández-Veledo S., Vendrell J., Joven J., Orozco M., Zorzano A., Scorrano L.: Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria// SCIENCE -Vol. 380,iss. 6651 (2023), s.1-13
DOI:
Digital Object Identifier (open in new tab) 10.1126/science.adh9351
Sources of funding:
  • COST_FREE
Verified by:
Gdańsk University of Technology

seen 38 times

Recommended for you

T cell Activation Is Driven by an ADP-Dependent Glukosinase Linking Enhanced Glycolysis with Mitochondrial Reactive Oxygen Species Generation

2012

The Unfolded Protein Response: A Double-Edged Sword for Brain Health

2023

Development of Safirinium dyes for new applications: fluorescent staining of bacteria, human kidney cells, and the horny layer of the epidermis

2022

From tryptophan to novel mitochondria-disruptive agent, synthesis and biological evaluation of 1,2,3,6-tetrasubstituted carbazoles

2022
Meta Tags