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• Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria

  Publication

  • D. Naón
  • M. I. Hernández-Alvarez
  • S. Shinjo
  • M. Wieczór
  • S. Ivanova
  • O. Martins de Brito
  • A. Quintana
  • J. Hidalgo
  • M. Palacín
  • P. Aparicio... and 9 others

  - SCIENCE - Year 2023

  In eukaryotic cells, different organelles interact at membrane contact sites stabilized by tethers. Mitochondrial mitofusin 2 (MFN2) acts as a membrane tether that interacts with an unknown partner on the endoplasmic reticulum (ER). In this work, we identified the MFN2 splice variant ERMIT2 as the ER tethering partner of MFN2. Splicing of MFN2 produced ERMIT2 and ERMIN2, two ER-specific variants. ERMIN2 regulated ER morphology,...

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