Synthesis of 3-Carbamoyl b-Lactams via Manganese(III)-Promoted Cyclization of N-Alkenylmalonamides - Publication - Bridge of Knowledge

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Synthesis of 3-Carbamoyl b-Lactams via Manganese(III)-Promoted Cyclization of N-Alkenylmalonamides

Abstract

Manganese(III)-promoted cyclization of N-alkenylmalonamides (¼N-alkenylpropanediamides) gave 3-(aryl/(alkylamino)carbonyl) b-lactams as well as 3-(aryl/(alkylamino)thiocarbonyl) b-lactams. The relative configuration of the obtained products was unambiguously determined by X-ray crystallography. The proposed method is very useful for the one-pot synthesis of a number of 3-(aryl/ (alkylamino)carbonyl) b-lactams, especially those containing an amino(thiocarbonyl) moiety, which are not selectively accessible by other methods

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DOI:
Digital Object Identifier (open in new tab) 10.1002/hlca.201200646
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Copyright (2013 Verlag Helvetica Chimica Acta AG, Zürich)

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Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
HELVETICA CHIMICA ACTA no. 96, edition 11, pages 2081 - 2091,
ISSN: 0018-019X
Language:
English
Publication year:
2013
Bibliographic description:
Punda P., Ponikiewski Ł., Makowiec S.: Synthesis of 3-Carbamoyl b-Lactams via Manganese(III)-Promoted Cyclization of N-Alkenylmalonamides// HELVETICA CHIMICA ACTA. -Vol. 96, iss. 11 (2013), s.2081-2091
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Gdańsk University of Technology

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