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Abstract
A series of novel phosphorus tacrine derivatives was obtained in three steps, including synthesis of 9-chlorotacrine, connection of 9-chlorotacrine with hexamethylenediamine, 1,8-diaminooctane and 1,12-diaminododecane linkers and reaction of obtained tacrine diamine analogues with corresponding acid ester to give nine tacrine organophosphorus compounds. All of the obtained final structures were characterized by 1H NMR, 13C NMR, 31P NMR and MS. _______
Authors (3)
-
Iwona Stepniak-inkielewicz dr hab.
- Gdański Uniwersytet Medyczny
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- Category:
- Conference activity
- Type:
- publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
- Language:
- English
- Publication year:
- 2019
- Bibliographic description:
- Przybyłowska M., Dzierzbicka K., Stepniak-Inkielewicz I.: SYNTHESIS OF PHOSPHORUS TACRINE ANALOGUES AS A NEW POTENTIAL ANTI-ALZHEIMER’S DISEASE AGENTS// / : , 2019,
- Verified by:
- Gdańsk University of Technology
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