Search
Abstract
Inefficient transportation of polar metabolic inhibitors through cell membranes of eukaryotic and prokaryotic cells precludes their direct use as drug candidates in chemotherapy. One of the possible solutions to this problem is application of the ‘Trojan horse’ strategy, i.e. conjugation of an active substance with a molecular carrier of organic or inorganic nature, facilitating membrane penetration. In this work, the synthetic strategies used in rational design and preparation of conjugates of bioactive agents with three types of organic low molecular-weight carriers have been reviewed. These include iron-chelating agents, siderophores and cell-penetrating peptides. Moreover, a less known but very promising “molecular umbrella” conjugation strategy has been presented. Special attention has been paid on appropriate linking strategies, especially these allowing intracellular drug release after internalisation of a conjugate.
Citations
-
3
CrossRef
-
0
Web of Science
-
3
Scopus
Authors (3)
Cite as
Full text
- Publication version
- Accepted or Published Version
- License
-
open in new tab
Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
BIOORGANIC CHEMISTRY
no. 104,
ISSN: 0045-2068 - Language:
- English
- Publication year:
- 2020
- Bibliographic description:
- Skwarecki A., Nowak M., Milewska M.: Synthetic strategies in construction of organic low molecular-weight carrier-drug conjugates// BIOORGANIC CHEMISTRY -Vol. 104, (2020), s.104311-
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.bioorg.2020.104311
- Verified by:
- Gdańsk University of Technology
seen 143 times
Recommended for you
Synthesis of green benzamide-decorated UiO-66-NH2 for biomedical applications
- N. Rabiee,
- A. M. Ghadiri,
- V. Alinezhad
- + 9 authors
Tailor-Made Polysaccharides for Biomedical Applications
- M. Khodadadiyazdi,
- F. Seidi,
- A. Hejna
- + 5 authors
Foliate-Targeting Quantum Dots-β-Cyclodextrin Nanocarrier for Efficient Delivery of Unsymmetrical Bisacridines to Lung and Prostate Cancer Cells
- J. Pilch,
- P. Kowalik,
- A. Kowalczyk
- + 5 authors