Search
Abstract
Many antimicrobial drugs are poorly active against pathogenic microbes causing intracellular infections, such as Mycobacterium tuberculosis or Plasmodium falciparum. On the other hand, several known antimicrobial agents are not effective enough because of their limited cellular penetration. A common feature of both challenges is the inability of an active agent to cross the biological membrane(s). One of the possible approaches facing these challenges is conjugation of an active substance with a molecular organic nanocarrier. The conjugate thus formed should be able to penetrate the membrane(s) and, once internalized, the active component could reach its intracellular target, either after release from the conjugate or in an intact form. Several molecular nanocarriers have been proposed: oligopeptides, including cell penetrating peptides, carbon nanotubes, siderophores, dendrimers, terpenoids and molecular umbrellas. A comprehensive review of the current status of molecular organic nanocarrier–drug conjugates and the future perspectives of their application as novel antimicrobials is presented.
Citations
-
3 4
CrossRef
-
0
Web of Science
-
3 4
Scopus
Authors (4)
Cite as
Full text
full text is not available in portal
Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
Nanomedicine-Nanotechnology Biology and Medicine
no. 12,
edition 8,
pages 2215 - 2240,
ISSN: 1549-9634 - Language:
- English
- Publication year:
- 2016
- Bibliographic description:
- Skwarecki A., Milewski S., Schielmann M., Milewska M.: Antimicrobial molecular nanocarrier–drug conjugates// Nanomedicine-Nanotechnology Biology and Medicine. -Vol. 12, iss. 8 (2016), s.2215-2240
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.nano.2016.06.002
- Verified by:
- Gdańsk University of Technology
seen 128 times
Recommended for you
Peptide dendrimers as antifungal agents and carriers for potential antifungal agent—N3‐(4‐methoxyfumaroyl)‐(S)‐2,3‐ diaminopropanoic acid—synthesis and antimicrobial activity
- M. Stolarska,
- K. Gucwa,
- Z. Urbańczyk-Lipkowska
- + 1 authors
Peptide conjugates of lactoferricin analogues and antimicrobials—Design, chemical synthesis, evaluation of antimicrobial activity and mammalian cytotoxicity
- N. Ptaszyńska,
- K. Olkiewicz,
- J. Okońska
- + 9 authors