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• Chloroacridine derivatives as potential anticancer agents which may act as tricarboxylic acid cycle enzyme inhibitors

  Publication

  • M. Cichorek
  • A. Ronowska
  • K. Dzierzbicka
  • M. Gensicka-Kowalewska
  • M. Deptuła
  • I. Pelikant-Malecka

  - BIOMEDICINE & PHARMACOTHERAPY - Year 2020

  The chloroacridines affect biological forms of melanoma in different ways. Amelanotic (Ab) melanoma (with inhibited melanogenesis and higher malignancy) was particularly sensitive to the action of the chloroacridines. The Ab melanoma cells died through apoptosis and through death without caspase activation. Diminished activity of TAC enzymes was noticed among Ab melanoma cells together with ATP/NAD depletion, especially in the...

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