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Search results for: EPIGENETIC REMODELLING

  • Transcriptional activity of epigenetic remodeling genes declines in keratinocytes after in vitro expansion

    Publication

    - Advances in Medical Sciences - Year 2019

    PURPOSE: In vitro expansion is an invaluable method to obtain keratinocytes in amounts necessary for effective transplantation therapies. In vitro cell culturing provokes questions concerning potential epigenetic alterations occurring in expanded cells in the context of usefulness for transplantation and safety. The purpose of this study was to investigate as to whether keratinocyte expansion is associated with changes in the activity...

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  • The role of epigenetics in regeneration

    Publication

    Complex changes in chromatin structure and at the transcriptional level occur from the creation of a single parental gamete throughout fertilization, embryo development and the life of an adult organism. Epigenetic changes, such as methylation and hydroxymethylation of DNA or histone methylation and acetylation, are an important part of these processes. Epigenetic regulation has an essential influence on gene expression level. DNA...

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  • Genetic and Epigenetic Aspects of Atopic Dermatitis

    Publication
    • B. Nedoszytko
    • E. Reszka
    • D. Gutowska-Owsiak
    • M. Trzeciak
    • M. Lange
    • J. Jarczak
    • M. Niedoszytko
    • E. Jablonska
    • J. Romantowski
    • D. Strapagiel... and 6 others

    - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2020

    Atopic dermatitis is a heterogeneous disease, in which the pathogenesis is associated with mutations in genes encoding epidermal structural proteins, barrier enzymes, and their inhibitors; the role of genes regulating innate and adaptive immune responses and environmental factors inducing the disease is also noted. Recent studies point to the key role of epigenetic changes in the development of the disease. Epigenetic modifications...

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  • Genetics & Epigenetics

    Journals

    ISSN: 1179-237X

  • Epigenetics & Chromatin

    Journals

    ISSN: 1756-8935