Year 2023

• Modified Peptide Molecules As Potential Modulators of Shelterin Protein Functions; TRF1

  Publication

  • W. Brankiewicz
  • U. Kalathiya
  • M. Padariya
  • K. Wegrzyn
  • M. Prusinowski
  • J. Żebrowska
  • A. Zylicz-Stachula
  • P. Skowron
  • M. Drab
  • M. Szajewski... and 5 others

  - CHEMISTRY-A EUROPEAN JOURNAL - Year 2023

  In this work, we present studies on relatively new and still not well-explored potential anticancer targets which are shelterin proteins, in particular the TRF1 protein can be blocked by in silico designed "peptidomimetic" molecules. TRF1 interacts directly with the TIN2 protein, and this protein-protein interaction is crucial for the proper functioning of telomere, which could be blocked by our novel modified peptide molecules....

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Year 2022

• Organic solvents aggregating and shaping structural folding of protein, a case study of the protease enzyme

  Publication

  • M. Padariya
  • M. Bagiński
  • M. Babak
  • U. Kalathiya

  - BIOPHYSICAL CHEMISTRY - Year 2022

  Low solubility of reactants or products in aqueous solutions can result in the enzymatic catalytic reactions that can occur in non-aqueous solutions. In current study we investigated aqueous solutions containing different organic solvents / deep eutectic solvents (DESs) that can influence the protease enzyme's activity, structural, and thermal stabilities. Retroviral aspartic protease enzyme is responsible for the cleavage of the...

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Year 2021

• Functional Interfaces, Biological Pathways, and Regulations of Interferon-Related DNA Damage Resistance Signature (IRDS) Genes

  Publication

  • M. Padariya
  • A. Sznarkowska
  • S. Kote
  • M. Gómez-Herranz
  • S. Mikac
  • M. Pilch
  • J. Alfaro
  • R. Fahraeus
  • T. Hupp
  • U. Kalathiya

  - Biomolecules - Year 2021

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• Interfaces with Structure Dynamics of the Workhorses from Cells Revealed through Cross-Linking Mass Spectrometry (CLMS)

  Publication

  • U. Kalathiya
  • M. Padariya
  • J. Faktor
  • E. Coyaud
  • J. Alfaro
  • R. Fahraeus
  • T. Hupp
  • D. Goodlett

  - Biomolecules - Year 2021

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• Multivalent Display of SARS-CoV-2 Spike (RBD Domain) of COVID-19 to Nanomaterial, Protein Ferritin Nanocages

  Publication

  • U. Kalathiya
  • M. Padariya
  • R. Fahraeus
  • S. Chakraborti
  • T. Hupp

  - Biomolecules - Year 2021

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• Viruses, cancer and non-self recognition

  Publication

  • M. Padariya
  • U. Kalathiya
  • S. Mikac
  • K. Dziubek
  • M. Tovar
  • E. Sroka
  • R. Fahraeus
  • A. Sznarkowska

  - Open Biology - Year 2021

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Year 2020

• Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site

  Publication

  • U. Kalathiya
  • M. Padariya
  • M. Mayordomo
  • M. Lisowska
  • J. Nicholson
  • A. Singh
  • M. Baginski
  • R. Fåhraeus
  • N. Carragher
  • K. Ball... and 4 others

  - Year 2020

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• Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site

  Publication

  • U. Kalathiya
  • M. Padariya
  • M. Mayordomo
  • M. Lisowska
  • J. Nicholson
  • A. Singh
  • M. Bagiński
  • R. Fahraeus
  • N. Carragher
  • K. Ball... and 4 others

  - Journal of Clinical Medicine - Year 2020

  An important stage in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) life cycle is the binding of the spike (S) protein to the angiotensin converting enzyme-2 (ACE2) host cell receptor. Therefore, to explore conserved features in spike protein dynamics and to identify potentially novel regions for drugging, we measured spike protein variability derived from 791 viral genomes and studied its properties by molecular...

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• Nonsense-Mediated mRNA Decay: Pathologies and the Potential for Novel Therapeutics

  Publication

  • K. Pawlicka
  • U. Kalathiya
  • J. Alfaro

  - Cancers - Year 2020

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• Recognition Dynamics of Cancer Mutations on the ERp57-Tapasin Interface

  Publication

  • M. Padariya
  • U. Kalathiya
  • D. Houston
  • J. Alfaro

  - Cancers - Year 2020

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Year 2019

• Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP-Binding Sites of NMD Master Regulator: UPF1

  Publication

  • . Kalathiya
  • . Padariya
  • . Pawlicka
  • . Verma
  • . Houston
  • . Hupp
  • . Alfaro
  • U. Kalathiya

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2019

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Year 2017

• Molecular basis of TRF proteins and their interactions with peptides

  Publication

  • U. Kalathiya
  • M. Padariya
  • M. Baginski

  - Acta Crystallographica A-Foundation and Advances - Year 2017

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• Structural analysis and predicting effects of natural mutations on telomerase

  Publication

  • M. Padariya
  • U. Kalathiya
  • M. Baginski

  - Acta Crystallographica A-Foundation and Advances - Year 2017

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Year 2014

• Inhibiting Activity of HIV-1: Protease, Reverse Transcriptase and Integrase All Together by Novel Compounds Using Computational Approaches

  Publication

  • U. Kalathiya
  • M. Padariya

  - International Journal of Bioscience, Biochemistry and Bioinformatics - Year 2014

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