Year 2015

• Structural factors affecting affinity of cytotoxic oxathiole-fused chalcones toward tubulin

  Publication

  • M. T. Konieczny
  • A. Buɬakowska
  • D. Pirska
  • W. Konieczny
  • A. Składanowski
  • M. Sabisz
  • M. Wojciechowski
  • K. Lemke
  • A. Pieczykolan
  • W. Strożek

  - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - Year 2015

  Synthesis, in vitro cytotoxic activity, and interaction with tubulin of (E)-1-(6-alkoxybenzo[d][1,3]oxathiol- 5-yl)-3-phenylprop-2-en-1-one derivatives (2) are described. Some of the compounds demonstrated cytotoxic activity at submicromolar concentrations, and the activity could be related to interaction with tubulin at the colchicine binding site. Interaction of selected derivatives with tubulinwas evaluated using molecular modeling,...

  Full text to download in external service

Year 2011

• New Chalcones Derivatives With Potent Antitumor Activity And Their Metabolism In Vitro

  Publication

  • M. Serocki
  • M. Sabisz
  • A. Bułakowska
  • M. T. Konieczny
  • A. Pieczykolan
  • M. Głazka
  • K. Wiciejowska
  • W. Strożek
  • J. Pieczykolan
  • K. Lemke
  • A. Składanowski

  - Acta Biochimica Polonica - Year 2011

  Chalcone derivatives exhibit a broad range of biological activities, with antioxidant and cytotoxic properties among the most studied. Despite numerous reports on chalcones as cytotoxic, and potentially anticancer agents, very little is know on their actual mechanism of activity. Generally, chalcones are considered as antimitotic agents, which interfere with tubulin assembly.We have recently developed a new class of chalcones with...

  Full text to download in external service