Karolina Wąsik - Publications - Bridge of Knowledge

Karolina Wąsik

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Year 2021

Iso-Partricin, an Aromatic Analogue of Amphotericin B: How Shining Light on Old Drugs Might Help Create New Ones
Publication
- P. Szczeblewski
- J. Górska
- W. Andrałojć
- P. Janke
- K. Wąsik
- T. Laskowski
- Antibiotics-Basel - Year 2021
Partricin is a heptaene macrolide antibiotic complex that exhibits exceptional antifungal activity, yet poor selective toxicity, in the pathogen/host system. It consists of two compounds, namely partricin A and B, and both of these molecules incorporate two cis-type bonds within their heptaenic chromophores: 28Z and 30Z. In this contribution, we have proven that partricins are susceptible to a chromophore-straightening photoisomerization...

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