Search results for: aureofacin

• Ipertrofan Revisited—The Proposal of the Complete Stereochemistry of Mepartricin A and B

  Publication

  • P. Szczeblewski
  • W. Andrałojć
  • J. Polit
  • A. Żabka
  • K. Winnicki
  • T. Laskowski

  - MOLECULES - Year 2021

  Being a methyl ester of partricin, the mepartricin complex is the active substance of a drug called Ipertrofan (Tricandil), which was proven to be useful in treatment of benign prostatic hyperplasia and chronic nonbacterial prostatitis/chronic pelvic pain syndrome. Nevertheless, no direct structural evidence on the stereochemistry of its components has been presented to date. In this contribution, we have conducted detailed, NMR-driven...

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• Iso-Partricin, an Aromatic Analogue of Amphotericin B: How Shining Light on Old Drugs Might Help Create New Ones

  Publication

  • P. Szczeblewski
  • J. Górska
  • W. Andrałojć
  • P. Janke
  • K. Wąsik
  • T. Laskowski

  - Antibiotics-Basel - Year 2021

  Partricin is a heptaene macrolide antibiotic complex that exhibits exceptional antifungal activity, yet poor selective toxicity, in the pathogen/host system. It consists of two compounds, namely partricin A and B, and both of these molecules incorporate two cis-type bonds within their heptaenic chromophores: 28Z and 30Z. In this contribution, we have proven that partricins are susceptible to a chromophore-straightening photoisomerization...

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