Year 2016

• Synthesis and biological evaluation of fluorinated 3-phenylcoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors

  Publication

  • S. Demkowicz
  • M. Daśko
  • W. Kozak
  • K. Krawczyk
  • D. Witt
  • M. Masłyk
  • K. Kubiński
  • J. Rachoń

  - Chemical Biology & Drug Design - Year 2016

  In the present work, we report the initial results of our study on a series of 3-phenylcoumarin sulfamate-based compounds containing C-F bonds as a novel inhibitors of steroid sulfatase (STS). The new compounds are potent STS inhibitors, possessing more than 10 times higher inhibitory potency than coumarin-7-O-sulfamate. In the course of our investigation, compounds 2b and 2c demonstrated the highest inhibitory effect in the enzymatic...

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