Year 2016

• Intramolecular transformation of an antifungal antibiotic nystatin A1 into its isomer, iso-nystatin A1 - structural and molecular modeling studies

  Publication

  • K. Szwarc-Karabyka
  • M. Płosiński
  • K. Czerniejewska
  • T. Laskowski
  • A. Leniak
  • J. Czub
  • P. Kubica
  • P. Sowiński
  • J. Pawlak
  • E. Borowski

  - MAGNETIC RESONANCE IN CHEMISTRY - Year 2016

  Nystatin A1, a polyene macrolide antifungal antibiotic, in a slightly basic or acidic solution undergoes an intramolecular transformation, yielding a structural isomer, the translactonization product, iso-nystatin A1 with lactone ring diminished by two carbon atoms. Structural evidence is provided by advanced NMR and Mass Spectrometry (MS) studies. Molecular dynamics simulations and quantum mechanics calculations gave the insight...

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Year 2012

• Stereostructure of mycoheptin A2

  Publication

  • M. Płosiński
  • T. Laskowski
  • P. Sowiński
  • J. Pawlak

  - MAGNETIC RESONANCE IN CHEMISTRY - Year 2012

  The absolute configurations of all the stereogenic centers of the antibiotic mycoheptin A2 were established upon previously elaborated general procedure, consisting of DQF-COSY, NOESY, ROESY, HSQC and HMBC experiments as major tools. The structure of mycoheptin A2 without stereochemistry of its aglycone has been reported before.

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• Stereostructure of mycoheptin A2

  Publication

  • M. Płosiński
  • T. Laskowski
  • P. Sowiński
  • J. Pawlak

  - MAGNETIC RESONANCE IN CHEMISTRY - Year 2012

  The absolute configurations of all the stereogenic centers of the antibiotic mycoheptin A2 were established upon previouslyelaborated general procedure, consisting of DQF-COSY, NOESY, ROESY, HSQC and HMBC experiments as major tools. Thestructure of mycoheptin A2 without stereochemistry of its aglycone has been reported before.

Year 2006

• Monosaccharides as internal probes for the determination of the absolute configuration of 2-butanol

  Publication

  • P. Seroka
  • M. Płosiński
  • J. Czub
  • P. Sowiński
  • J. Pawlak

  - MAGNETIC RESONANCE IN CHEMISTRY - Year 2006

  D-dlukoza, D-mannoza i L-ramnoza zostały poddane reakcji z mieszaniną racemiczną 2-butanolu. Otrzymane w ten sposób glikozydy były analizowane za pomocą spektroskopii NMR, z wykorzystaniem eksperymentów COSY i NOESY. Analiza konformacyjna wiązania glikozydowego (dokonana w oparciu o modelowanie molekularne i heteronuklearne stałe sprzężenia) wraz z analizą sprzężeń dipolowych obserwowanych w widmie NOESY umożliwiła określenie konfiguracji...

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