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Description
The datasets contain the results of new bisacridines IKE16, IKE18 and IE10 inhibition activity against yeast topoisomerase II. DNA topoisomerases (Topo) are enzymes that catalyze changes in the spatial structure of DNA and play an important role in replication, transcription and recombination. Beyond their normal functions, DNA topo are significant molecular target in antimicrobial and anticancer chemotherapy.
Inhibition of Yeast Topoisomerase II were analysed according to the relaxation assay kit from Inspiralis. The results were analysed on the 1% agarose gel in 1x TAE buffer, 3h, 4.5 V cm -1. Gel was stained in GelRed 3x staining solution for 30 min and photographed with Gel Doc XR+Gel Documentation System.
Dataset file
IE7, IKE18, IKE16 RA.zip
12.1 MB,
S3 ETag
38b3bc096c5322f3ca12218c63aa9788-1,
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File details
- License:
-
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CC BY-NC-SANon-commercial - Share-alike
Details
- Year of publication:
- 2023
- Verification date:
- 2023-09-28
- Dataset language:
- English
- Fields of science:
-
- chemical sciences (Natural sciences)
- DOI:
- DOI ID 10.34808/bw93-c545 open in new tab
- Funding:
- Series:
- Verified by:
- Gdańsk University of Technology
Keywords
References
- dataset Determination of the minimum inhibitory concentration of new bisacridines IKE15-19 and IKE21, against yeast strains
- dataset The absorption and fluorescence spectra of novel bisacridines (IKE15-19, IKE21) and IE10, potential antifungal agents
- dataset Determination of the MIC (minimum inhibitory concentration) of new bisacridines IKE16-19, IKE21 and IE10 against C. glabrata clinical strains
- dataset Effect of novel bisacridines (IKE16, IKE18, IKE19, IKE21) and IE10 on the biofilm formation of C. albicans ATCC 10231 cells
- dataset Determination of cytotoxic activity of new bisacridines IKE18, IKE19, IKE21 and IE10 against human kidney HEK-293 (ATCC® CRL-1573™) and liver cells HEPG2 (ATCC® HB-8065™)
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