Minimum inhibitory concentrations (MICs) determination of selected human topoisomerase II alpha and bacterial DNA gyrase inhibitors against fungal strains

Description

The datasets contain the results of determining the MIC (Minimal Inhibitory Concentration) value of known compounds* (inhibitors of human topoisomerase II alpha and bacterial DNA gyrase) against C. albicans SC5314, C. glabrata ATCC 90030, C. krusei ATCC 6258 and C. parapsilosis ATCC 22019 and Saccharomyces cerevisiae ATCC 9763 by the modified M27-A3 specified by the CLSI.

*Compounds:

ciprofloxacin
levofloxacin
etoposide
quinacrine
bisantrene
pixantrone
resveratrol
teniposide
dexrazoxane
mitoxantrone
daunorubicin
doxorubicin
epirubicin
idarubicin
valrubicin
merbarone
novobiocin

Dataset file

MIC inhibitors hTOPOII, DNA gyrase.zip

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CC BY

Attribution
Raw data:: Data contained in dataset was not processed.
Software:: Excel

Details

Year of publication:

2024

Verification date:

2024-07-03

Dataset language:

English

Fields of science:

chemical sciences (Natural sciences)

DOI:

10.34808/0kz4-y909

Funding:

Yeast DNA topoisomerase II as a model molecular target for novel antifungal compounds

Verified by:

Gdańsk University of Technology

Keywords

References

dataset Effect of antitumor compounds on the yeast topoisomerase II relaxation activity

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