4-(Cyclic-amidino)phenols. Preparation and Use in a Diamidine Synthesis

Jaroslaw Spychala

doi:https://doi.org/10.1080/00397910008087126

4-(Cyclic-amidino)phenols. Preparation and Use in a Diamidine Synthesis

Abstract

The Pinner synthesis was applied to the prepn. of phenols 4-substituted with cyclic amidines in high yields from readily available 4-HOC6H4C(OMe):NH.HCl and aliph. diamines. An alternative attempt was made to convert 4-HOC6H4CSNH2 to 4-(1,4,5,6-tetrahydro-5-hydroxy-2-pyrimidinyl)phenol. A procedure for the prepn. of 3,6-bis(4-hydroxyphenyl)-1,2,4,5-tetrazine is reported. The syntheses of 2,4-bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyrimidine and 2-chloro-4-[4-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyrimidine exemplify the use of the title compds. as synthetic intermediates.

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Jaroslaw Spychala dr

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Category:: Magazine publication
Type:: Magazine publication
Published in:: SYNTHETIC COMMUNICATIONS no. 30, edition 6, pages 1083 - 1094,
ISSN: 0039-7911
Publication year:: 2000
Bibliographic description:: Jaroslaw Spychala, 4-(Cyclic-amidino)phenols. Preparation and Use in a Diamidine Synthesis, Synthetic Communications, vol. 30(6), pages 1083-1094, 2000.
DOI:: Digital Object Identifier (open in new tab) https://doi.org/10.1080/00397910008087126
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