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A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants
Abstract
The World Health Organization Global Action Plan recommends integrated surveillance programs as crucial strategies for monitoring antibiotic resistance. Although several national surveillance programs are in place for clinical and veterinary settings, no such schemes exist for monitoring antibiotic-resistant bacteria in the environment. In this transnational study, we developed, validated, and tested a low-cost surveillance and easy to implement approach to evaluate antibiotic resistance in wastewater treatment plants (WWTPs) by targeting cefotaxime-resistant (CTX-R) coliforms as indicators. The rationale for this approach was: i) coliform quantification methods are internationally accepted as indicators of fecal contamination in recreational waters and are therefore routinely applied in analytical labs; ii) CTX-R coliforms are clinically relevant, associated with extended-spectrum β-lactamases (ESBLs), and are rare in pristine environments. We analyzed 57 WWTPs in 22 countries across Europe, Asia, Africa, Australia, and North America. CTX-R coliforms were ubiquitous in raw sewage and their relative abundance varied significantly (<0.1% to 38.3%), being positively correlated (p < 0.001) with regional atmospheric temperatures. Although most WWTPs removed large proportions of CTX-R coliforms, loads over 103 colony-forming units per mL were occasionally observed in final effluents. We demonstrate that CTX-R coliform monitoring is a feasible and affordable approach to assess wastewater antibiotic resistance status.
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Authors (85)
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Roberto Marano
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Telma Fernandes
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Celia M. Manaia
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Olga Nunes
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Donald Morrison
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Thomas U. Berendonk
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Norbert Kreuzinger
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Tanel Telson
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Gianluca Corno
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Despo Fatta-Kassinos
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Christophe Merlin
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Edward Topp
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Edouard Jurkevitch
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Leonie Henn
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Andrew Scott
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Stefanie Hess
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Katarzyna Slipko
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Mailis Laht
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Veljo Kisand
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Andrea Di Cesare
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Popi Karaolia
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Stella G. Michael
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Alice L Petre
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Roberto Rosal
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Amy Pruden
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Virgina Riquemle
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Ana Aguera
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Belen Esterban
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Anne Leonard
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William H. Gaze
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Anthony A. Adegooke
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Thor A. Stenstrom
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Alfieri Pollice
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Carlo Salerno
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Carsten U. Schwermer
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Paweł Krzemiński
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Helene Guilloteau
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Erica Donner
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Barbara Drigo
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Giovanni Libralato
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Marco Guida
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Helmut Burgmann
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Karin Beck
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Hemda Garelick
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Marta Tacao
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Isabel Henriques
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Isabel Martinez-Alcala
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Jose M. Guillien-Navarro
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Magdalena Popowska
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Marta Piotrowska
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Markos Quintela-Baluja
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Joshua T. Bunce
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Maria I. Polo-Lopez
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Samira Nahim-Granados
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Marie-Noelle Pons
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Milena Milakovic
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Nikolina Udikovic-Kolic
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Jerome Ory
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Traore Ousmane
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Pilar Caballero
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Antoni Oliver
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Sara Rodriguez-Mozaz
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Jose L. Balcazar
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Thomas Jager
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Thomas Schwartz
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Ying Yang
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Shichun Zou
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Yunho Lee
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Younggun Yoon
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Bastian Herzog
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Heidrun Mayrhofer
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Om Prakash
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Yogesh Nimonkar
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Ester Heath
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Anna Baraniak
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Joana Abreu-Silva
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Manika Choudhury
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Leonardo P. Munoz
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Stela Krizanovic
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Gianluca Brunetti
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Ayella Maile-Moskowitz
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Connor Brown
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Eddie Cytryn
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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ENVIRONMENT INTERNATIONAL
no. 144,
ISSN: 0160-4120 - Language:
- English
- Publication year:
- 2020
- Bibliographic description:
- Marano R., Fernandes T., Manaia C., Nunes O., Morrison D., Berendonk T., Kreuzinger N., Telson T., Corno G., Fatta-Kassinos D., Merlin C., Topp E., Jurkevitch E., Henn L., Scott A., Hess S., Slipko K., Laht M., Kisand V., Di Cesare A., Karaolia P., Michael S., Petre A., Rosal R., Pruden A., Riquemle V., Aguera A., Esterban B., Łuczkiewicz A., Kalinowska A., Leonard A., Gaze W., Adegooke A., Stenstrom T., Pollice A., Salerno C., Schwermer C., Krzemiński P., Guilloteau H., Donner E., Drigo B., Libralato G., Guida M., Burgmann H., Beck K., Garelick H., Tacao M., Henriques I., Martinez-Alcala I., Guillien-Navarro J., Popowska M., Piotrowska M., Quintela-Baluja M., Bunce J., Polo-Lopez M., Nahim-Granados S., Pons M., Milakovic M., Udikovic-Kolic N., Ory J., Ousmane T., Caballero P., Oliver A., Rodriguez-Mozaz S., Balcazar J., Jager T., Schwartz T., Yang Y., Zou S., Lee Y., Yoon Y., Herzog B., Mayrhofer H., Prakash O., Nimonkar Y., Heath E., Baraniak A., Abreu-Silva J., Choudhury M., Munoz L., Krizanovic S., Brunetti G., Maile-Moskowitz A., Brown C., Cytryn E.: A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants// ENVIRONMENT INTERNATIONAL -Vol. 144, (2020), s.106035-
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.envint.2020.106035
- Verified by:
- Gdańsk University of Technology
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