A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants - Publication - MOST Wiedzy


A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants


The World Health Organization Global Action Plan recommends integrated surveillance programs as crucial strategies for monitoring antibiotic resistance. Although several national surveillance programs are in place for clinical and veterinary settings, no such schemes exist for monitoring antibiotic-resistant bacteria in the environment. In this transnational study, we developed, validated, and tested a low-cost surveillance and easy to implement approach to evaluate antibiotic resistance in wastewater treatment plants (WWTPs) by targeting cefotaxime-resistant (CTX-R) coliforms as indicators. The rationale for this approach was: i) coliform quantification methods are internationally accepted as indicators of fecal contamination in recreational waters and are therefore routinely applied in analytical labs; ii) CTX-R coliforms are clinically relevant, associated with extended-spectrum β-lactamases (ESBLs), and are rare in pristine environments. We analyzed 57 WWTPs in 22 countries across Europe, Asia, Africa, Australia, and North America. CTX-R coliforms were ubiquitous in raw sewage and their relative abundance varied significantly (<0.1% to 38.3%), being positively correlated (p < 0.001) with regional atmospheric temperatures. Although most WWTPs removed large proportions of CTX-R coliforms, loads over 103 colony-forming units per mL were occasionally observed in final effluents. We demonstrate that CTX-R coliform monitoring is a feasible and affordable approach to assess wastewater antibiotic resistance status.


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Authors (85)

  • Photo of  Roberto Marano

    Roberto Marano

  • Photo of  Telma Fernandes

    Telma Fernandes

  • Photo of  Celia M. Manaia

    Celia M. Manaia

  • Photo of  Olga Nunes

    Olga Nunes

  • Photo of  Donald Morrison

    Donald Morrison

  • Photo of  Thomas U. Berendonk

    Thomas U. Berendonk

  • Photo of  Norbert Kreuzinger

    Norbert Kreuzinger

  • Photo of  Tanel Telson

    Tanel Telson

  • Photo of  Gianluca Corno

    Gianluca Corno

  • Photo of  Despo Fatta-Kassinos

    Despo Fatta-Kassinos

  • Photo of  Christophe Merlin

    Christophe Merlin

  • Photo of  Edward Topp

    Edward Topp

  • Photo of  Edouard Jurkevitch

    Edouard Jurkevitch

  • Photo of  Leonie Henn

    Leonie Henn

  • Photo of  Andrew Scott

    Andrew Scott

  • Photo of  Stefanie Hess

    Stefanie Hess

  • Photo of  Katarzyna Slipko

    Katarzyna Slipko

  • Photo of  Mailis Laht

    Mailis Laht

  • Photo of  Veljo Kisand

    Veljo Kisand

  • Photo of  Andrea Di Cesare

    Andrea Di Cesare

  • Photo of  Popi Karaolia

    Popi Karaolia

  • Photo of  Stella G. Michael

    Stella G. Michael

  • Photo of  Alice L Petre

    Alice L Petre

  • Photo of  Roberto Rosal

    Roberto Rosal

  • Photo of  Amy Pruden

    Amy Pruden

  • Photo of  Virgina Riquemle

    Virgina Riquemle

  • Photo of  Ana Aguera

    Ana Aguera

  • Photo of  Belen Esterban

    Belen Esterban

  • Photo of  Anne Leonard

    Anne Leonard

  • Photo of  William H. Gaze

    William H. Gaze

  • Photo of  Anthony A. Adegooke

    Anthony A. Adegooke

  • Photo of  Thor A. Stenstrom

    Thor A. Stenstrom

  • Photo of  Alfieri Pollice

    Alfieri Pollice

  • Photo of  Carlo Salerno

    Carlo Salerno

  • Photo of  Carsten U. Schwermer

    Carsten U. Schwermer

  • Photo of  Paweł Krzemiński

    Paweł Krzemiński

  • Photo of  Helene Guilloteau

    Helene Guilloteau

  • Photo of  Erica Donner

    Erica Donner

  • Photo of  Barbara Drigo

    Barbara Drigo

  • Photo of  Giovanni Libralato

    Giovanni Libralato

  • Photo of  Marco Guida

    Marco Guida

  • Photo of  Helmut Burgmann

    Helmut Burgmann

  • Photo of  Karin Beck

    Karin Beck

  • Photo of  Hemda Garelick

    Hemda Garelick

  • Photo of  Marta Tacao

    Marta Tacao

  • Photo of  Isabel Henriques

    Isabel Henriques

  • Photo of  Isabel Martinez-Alcala

    Isabel Martinez-Alcala

  • Photo of  Jose M. Guillien-Navarro

    Jose M. Guillien-Navarro

  • Photo of  Magdalena Popowska

    Magdalena Popowska

  • Photo of  Marta Piotrowska

    Marta Piotrowska

  • Photo of  Markos Quintela-Baluja

    Markos Quintela-Baluja

  • Photo of  Joshua T. Bunce

    Joshua T. Bunce

  • Photo of  Maria I. Polo-Lopez

    Maria I. Polo-Lopez

  • Photo of  Samira Nahim-Granados

    Samira Nahim-Granados

  • Photo of  Marie-Noelle Pons

    Marie-Noelle Pons

  • Photo of  Milena Milakovic

    Milena Milakovic

  • Photo of  Nikolina Udikovic-Kolic

    Nikolina Udikovic-Kolic

  • Photo of  Jerome Ory

    Jerome Ory

  • Photo of  Traore Ousmane

    Traore Ousmane

  • Photo of  Pilar Caballero

    Pilar Caballero

  • Photo of  Antoni Oliver

    Antoni Oliver

  • Photo of  Sara Rodriguez-Mozaz

    Sara Rodriguez-Mozaz

  • Photo of  Jose L. Balcazar

    Jose L. Balcazar

  • Photo of  Thomas Jager

    Thomas Jager

  • Photo of  Thomas Schwartz

    Thomas Schwartz

  • Photo of  Ying Yang

    Ying Yang

  • Photo of  Shichun Zou

    Shichun Zou

  • Photo of  Yunho Lee

    Yunho Lee

  • Photo of  Younggun Yoon

    Younggun Yoon

  • Photo of  Bastian Herzog

    Bastian Herzog

  • Photo of  Heidrun Mayrhofer

    Heidrun Mayrhofer

  • Photo of  Om Prakash

    Om Prakash

  • Photo of  Yogesh Nimonkar

    Yogesh Nimonkar

  • Photo of  Ester Heath

    Ester Heath

  • Photo of  Anna Baraniak

    Anna Baraniak

  • Photo of  Joana Abreu-Silva

    Joana Abreu-Silva

  • Photo of  Manika Choudhury

    Manika Choudhury

  • Photo of  Leonardo P. Munoz

    Leonardo P. Munoz

  • Photo of  Stela Krizanovic

    Stela Krizanovic

  • Photo of  Gianluca Brunetti

    Gianluca Brunetti

  • Photo of  Ayella Maile-Moskowitz

    Ayella Maile-Moskowitz

  • Photo of  Connor Brown

    Connor Brown

  • Photo of  Eddie Cytryn

    Eddie Cytryn


artykuły w czasopismach
Published in:
ISSN: 0160-4120
Publication year:
Bibliographic description:
Marano R., Fernandes T., Manaia C., Nunes O., Morrison D., Berendonk T., Kreuzinger N., Telson T., Corno G., Fatta-Kassinos D., Merlin C., Topp E., Jurkevitch E., Henn L., Scott A., Hess S., Slipko K., Laht M., Kisand V., Di Cesare A., Karaolia P., Michael S., Petre A., Rosal R., Pruden A., Riquemle V., Aguera A., Esterban B., Łuczkiewicz A., Kalinowska A., Leonard A., Gaze W., Adegooke A., Stenstrom T., Pollice A., Salerno C., Schwermer C., Krzemiński P., Guilloteau H., Donner E., Drigo B., Libralato G., Guida M., Burgmann H., Beck K., Garelick H., Tacao M., Henriques I., Martinez-Alcala I., Guillien-Navarro J., Popowska M., Piotrowska M., Quintela-Baluja M., Bunce J., Polo-Lopez M., Nahim-Granados S., Pons M., Milakovic M., Udikovic-Kolic N., Ory J., Ousmane T., Caballero P., Oliver A., Rodriguez-Mozaz S., Balcazar J., Jager T., Schwartz T., Yang Y., Zou S., Lee Y., Yoon Y., Herzog B., Mayrhofer H., Prakash O., Nimonkar Y., Heath E., Baraniak A., Abreu-Silva J., Choudhury M., Munoz L., Krizanovic S., Brunetti G., Maile-Moskowitz A., Brown C., Cytryn E.: A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants// ENVIRONMENT INTERNATIONAL -Vol. 144, (2020), s.106035-
Digital Object Identifier (open in new tab) 10.1016/j.envint.2020.106035
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Gdańsk University of Technology

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