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Abstract
One of the important areas of modern science is the selection of the right forms of drug delivery. Layered inorganic nanoparticles, such as zirconium phosphate, have proven themselves well in this area. The study of the properties of these systems and methods of their preparation makes it possible to determine a rational technology of their manufacture, storage conditions as well as suggest a possible mechanism of therapeutic action. The physical dimensions of the formed aggregates, morphology and structure are often the most influential factors for controlling the active surface area, reactivity, bioavailability and toxicity of nanoparticles. Aggregation properties of zirconium phosphate nanoparticles loaded with cluster rhenium(III) compounds with propionate ligands of different structure types (di-, tri- and tetra-carboxylates) and cisplatin were investigated by laser diffraction method in water. It was shown that the quantity and orientation of propionate ligands affect the aggregation properties of the investigated compounds. However, the presence of cisplatin in the composites reduced the aggregation abilities of the nanoparticles which indicate the formation of new complexes on their surfaces. After sonication, cisplatinrhenium compound composites had practically the same size-distribution curves. Our findings showed that the formation of different complexes with ZrP occurs on the surfaces depending from the structure of the rhenium substances.
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Authors (5)
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A. Slipkan
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Natalia Shtemenko
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Aleksander Shtemenko
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- Category:
- Articles
- Type:
- publikacja w in. zagranicznym czasopiśmie naukowym (tylko język obcy)
- Published in:
-
Vaprosy Khimii i Khimicheskoi Tekhnologii
edition 6,
pages 72 - 76,
ISSN: 0321-4095 - Language:
- English
- Publication year:
- 2018
- Bibliographic description:
- Slipkan A., Shtemenko, N., Bray R., Obarska-Pempkowiak H., Shtemenko, A.. Aggregation properties of some zirconium phosphate loaded with dirhenium(III) complexes. Vaprosy Khimii i Khimicheskoi Tekhnologii, 2018, , iss. 6, s.72-76
- DOI:
- Digital Object Identifier (open in new tab) 10.32434/0321-4095-2018-121-6-72-76
- Verified by:
- Gdańsk University of Technology
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