Anomalous Behavior of Hyaluronan Crosslinking Due to the Presence of Excess Phospholipids in the Articular Cartilage System of Osteoarthritis - Publication - Bridge of Knowledge

Search

Anomalous Behavior of Hyaluronan Crosslinking Due to the Presence of Excess Phospholipids in the Articular Cartilage System of Osteoarthritis

Abstract

Lubrication of articular cartilage is a complex multiscale phenomenon in synovial joint organ systems. In these systems, synovial fluid properties result from synergistic interactions between a variety of molecular constituent. Two molecular classes in particular are of importance in understanding lubrication mechanisms: hyaluronic acid and phospholipids. The purpose of this study is to evaluate interactions between hyaluronic acid and phospholipids at various functionality levels during normal and pathological synovial fluid conditions. Molecular dynamic simulations of hyaluronic acid and phospholipids complexes were performed with the concentration of hyaluronic acid set at a constant value for two organizational forms, extended (normal) and coiled (pathologic). The results demonstrated that phospholipids affect the crosslinking mechanisms of hyaluronic acid significantly and the influence is higher during pathological conditions. During normal conditions, hyaluronic acid and phospholipid interactions seem to have no competing mechanism to that of the interaction between hyaluronic acid to hyaluronic acid. On the other hand, the structures formed under pathologic conditions were highly affected by phospholipid concentration.

Citations

  • 1 3

    CrossRef

  • 0

    Web of Science

  • 1 3

    Scopus

Authors (7)

Cite as

Full text

download paper
downloaded 45 times
Publication version
Accepted or Published Version
License
Creative Commons: CC-BY open in new tab

Keywords

Details

Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES no. 18, pages 1 - 16,
ISSN: 1661-6596
Language:
English
Publication year:
2017
Bibliographic description:
Bełdowski P., Weber P., Andrysiak T., Auge W., Ledziński D., Deleon T., Gadomski A.: Anomalous Behavior of Hyaluronan Crosslinking Due to the Presence of Excess Phospholipids in the Articular Cartilage System of Osteoarthritis// INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. -Vol. 18, nr. 12 (2017), s.1-16
DOI:
Digital Object Identifier (open in new tab) 10.3390/ijms18122779
Bibliography: test
  1. Hari, G.G.; Hales, C.A. Chemistry and Biology of Hyaluronan; Elsevier Science: Amsterdam, The Netherlands, 2008; ISBN 9780080472225.
  2. Jung, S.; Petelska, A.; Bełdowski, P.; Augé, W.K.; Casey, T.; Walczak, D.; Lemke, K.; Gadomski, A. Hyaluronic acid and phospholipid interactions useful for repaired articular cartilage surfaces-a mini review toward tribological surgical adjuvants. Colloid Polym. Sci. 2017, 295, 403-412. open in new tab
  3. Siódmiak, J.; Bełdowski, P.; Augé, W.K., II; Ledziński, D.;Śmigiel, S.; Gadomski, A. Molecular Dynamic Analysis of Hyaluronic Acid and Phospholipid Interaction in Tribological Surgical Adjuvant Design for Osteoarthritis. Molecules 2017, 22, 1436. open in new tab
  4. Ganguly, K.; McRury, I.D.; Goodwin, P.M.; Morgan, R.E.; Augé, W.K. Native chondrocyte viability during cartilage lesion progression: Normal to surface fibrillation. Cartilage 2010, 1, 306-311. open in new tab
  5. Augé, W.K. Conceptualization of surface-confined nano-assemblies as a biophysical battery circuit during tissue rescue: A bridge to accessing genomic control mechanisms. Int. J. Nanosyst. 2012, 5, 1-18.
  6. Augé, W.K. Inverse mass ratio batteries: An in situ energy source generated from motive proton delivery gradients. Nano Energy 2012, 1, 309-315.
  7. Kwiecinski, J.J.; Dorosz, S.G.; Ludwig, T.E.; Abubacker, S.; Cowman, M.K.; Schmidt, T.A. The effect of molecular weight on hyaluronan's cartilage boundary lubricating ability-Alone and in combination with proteoglycan 4. Osteoarthr. Cartil. 2011, 19, 1356-1362. open in new tab
  8. Temple-Wong, M.M.; Ren, S.; Quach, P.; Hansen, B.C.; Chen, A.C.; Hasegawa, A.; D'Lima, D.D.; Koziol, J.; Masuda, K.; Lotz, M.K.; et al. Hyaluronan concentration and size distribution in human knee synovial fluid: Variations with age and cartilage degeneration. Arthritis Res. Ther. 2016, 18, 18. open in new tab
  9. Snelling, S.; Rout, R.; Davidson, R.; Clark, I.; Carr, A.; Hulley, P.A.; Price, A.J. A gene expression study of normal and damaged cartilage in anteromedial gonarthrosis, a phenotype of osteoarthritis. Osteoarthr. Cartil. 2014, 22, 334-343. open in new tab
  10. Band, P.A.; Heeter, J.; Wisniewski, H.G.; Liublinska, V.; Pattanayak, C.W.; Karia, R.J.; Stabler, T.; Balazs, E.A.; Kraus, V.B. Hyaluronan molecular weight distribution is associated with the risk of knee osteoarthritis progression. Osteoarthr. Cartil. 2015, 23, 70-76. open in new tab
  11. Bełdowski, P.; Augé, W.K.; Andrysiak, T.; Mrela, A.; Pawlak, Z.; Gadomski, A. The structural dependence of surface active phospholipid on hyaluronan molecular mass and concentration in model synovial joint organ systems. Polymers 2018, Submitted for publication. open in new tab
  12. Pasquali-Ronchetti, I.; Quaglino, D.; Mori, G.; Bacchelli, B.; Ghosh, P. Hyaluronan-phospholipid interactions. J. Struct. Biol. 1997, 120, 1-10. open in new tab
  13. Goychuk, I.; Hänggi, P. Fractional diffusion modeling of ion channel gating. Phys. Rev. E 2004, 70, 051915. open in new tab
  14. Goychuk, I.; Hänggi, P. The role of conformational diffusion in ion channel gating. Phys. A 2004, 325, 9-18. open in new tab
  15. Glöckle, W.G.; Nonnenmacher, T.F. A Fractional Calculus Approach to Self-Similar Protein Dynamics. Biophys. J. 1995, 68, 46-53. open in new tab
  16. Ślȩzak, J.; Weron, K. Revised approach to statistical analysis of ionic current fluctuations. Acta Phys. Pol. B 2012, 43, 1215-1226. open in new tab
  17. Gadomski, A.; Rubi, J.M.; Łuczka, J.; Ausloos, M. On temperature and space-dimension dependent matter agglomerations in mature growing stage. Chem. Phys. 2005, 310, 153-161. open in new tab
  18. Sorkin, R.; Kampf, N.; Zhu, L.; Klein, J. Hydration lubrication and shear-induced self-healing of lipid bilayer boundary lubricants in phosphatidylcholine dispersions. Soft Matter 2016, 12, 2773-2784. open in new tab
  19. Wang, M.; Liu, C.; Thormann, E.; Dédinaité, A. Hyaluronan and phospholipid association in biolubrication. Biomacromolecules 2013, 14, 4198-4206. open in new tab
  20. Kosińska, M.K.; Liebisch, G.; Lochnit, G.; Wilhelm, J.; Klein, H.; Kaesser, U.; Lasczkowski, G.; Rickert, M.; Schmitz, G.; Steinmeyer, J. A lipidomic study of phospholipid classes and species in human synovial fluid. Arthritis Rheum. 2013, 65, 2323-2333. open in new tab
  21. Kosińska, M.; Ludwig, T.E.; Liebisch, G.; Zhang, R.; Siebert, H.C.; Wilhelm, J.; Kaesser, U.; Dettmeyer, R.B.; Klein, H.; Ishaque, B.; et al. Articular joint lubricants during osteoarthritis and rheumatoid arthritis display altered levels and molecular species. PLoS ONE 2015, 10, e0125192. open in new tab
  22. Ermakov, S.; Beletskii, A.; Eismont, O.; Nikolaev, V. Liquid Crystals in Biotribology, Synovial Joint Treatment. Biological and Medicinal Physics; Biomedical Engineering; Springer International Publishing AG: Cham, Switzerland, 2016; ISBN 978-3-319-20348-5. open in new tab
  23. Das, S.; Banquy, X.; Zappone, B.; Israelachvili, J. Synergistic interactions between grafted hyaluronic acid and lubricin provide enhanced wear protection and lubrication. Biomacromolecules 2013, 14, 1669-1677. open in new tab
  24. Wierzcholski, K. Joint cartilage lubrication with phospholipid bilayer. Tribologia 2016, 2, 145-157. open in new tab
  25. Dédinaité, A. Biomimetic lubrication. Soft Matter 2012, 8, 273-284.
  26. Hills, B.A. Boundary lubrication in vivo. Proc. Inst. Mech. Eng. H 2000, 214, 83-94. open in new tab
  27. Greene, G.W.; Banquy, X.; Lee, D.W.; Lowrey, D.D.; Yu, J.; Israelachvili, J. Adaptive mechanically controlled lubrication mechanism found in articular joints. Proc. Nat. Acad. Sci. USA 2011, 108, 5255-5259. open in new tab
  28. Matej, D. Boundary cartilage lubrication: Review of current concepts. Wien. Med. Wochenschr. 2014, 164, 88-94.
  29. Wieland, D.C.F.; Degen, P.; Zander, T.; Gayer, S.; Raj, A.; An, J.; Dédinaité, A.; Claesson, P.; Willumeit-Römer, R. Structure of DPPC-hyaluronan interfacial layers-Effects of molecular weight and ion composition. Soft Matter 2016, 12, 729-740. open in new tab
  30. Scott, J.E.; Heatley, F. Biological Properties of Hyaluronan in Aqueous Solution Are Controlled and Sequestered by Reversible Tertiary Structures, Defined by NMR Spectroscopy. Biomacromolecules 2002, 3, 547-553. open in new tab
  31. Jenkins, S.; Jacob, K.I.; Kumar, S. The effect of hydrogen bonding on the physical and mechanical properties of rigid-rod polymers. J. Polym. Sci. Part B Polym. Phys. 2000, 38, 3053-3061. open in new tab
  32. Chen, Y.; Crawford, R.W.; Oloyede, A. Unsaturated phosphatidylcholines lining on the surface of cartilage and its possible physiological roles. J. Orthop. Surg. Res. 2007, 2, 14. open in new tab
  33. Lee, D.W.; Banquy, X.; Das, S.; Cadirov, N.; Jay, G.; Israelachvili, J. Effects of molecular weight of grafted hyaluronic acid on wear initiation. J. Acta Biomater. 2014, 10, 1817-1823. open in new tab
  34. Banquy, X.; Lee, D.W.; Das, S.; Israelachvili, J. Shear-induced aggregation of mammalian synovial fluid components under boundary lubrication conditions. Adv. Funct. Mater. 2014, 24, 3152-3161. open in new tab
  35. Nitzan, D.W.; Nitzan, U.; Dan, P.; Yedgar, S. The role of hyaluronic acid in protecting surface-active phospholipids from lysis by exogenous phospholipase A2. Rheumatology 2001, 40, 335-340. open in new tab
  36. Pathak, P.; London, F. The effect of membrane lipid composition on the formation of lipid ultrananodomains. Biophys. J. 2015, 109, 1630-1638. open in new tab
  37. Raj, A.; Wang, M.; Zander, T.; Wieland, D.C.F.; Liu, X.; An, J.; Garamus, V.M.; Willumeit-Römer, R.; Fielden, M.; Claesson, P.M.; et al. Lubrication synergy: Mixture of hyaluronan and dipalmitoylphosphatidylcholine (DPPC) vesicles. J. Colloid Inter. Sci. 2017, 488, 225-233. open in new tab
  38. Goudoulas, T.B.; Kastrinakis, E.G.; Nychas, S.G.; Papazoglou, L.G.; Kazakos, G.M.; Kosmas, P.V. Rheological study of synovial fluid obtained from dogs: Healthy, pathological, and post-surgery, after spontaneous rupture of cranial cruciate ligament. Ann. Biomed. Eng. 2010, 38, 57-65. open in new tab
  39. Bełdowski, P.; Winkler, R.G.; Hładyszowski, J.; Jung, S.; Gadomski, A. Shape Change of Micelles Dragged with Constant Velocity as Addressed in Terms of Biolubrication Application. Acta Phys. Pol. A 2016, 129, 188-189. open in new tab
  40. Gadomski, A.; Pawlak, Z.; Oloyede, A. Directed ion transport as virtual cause of some facilitated friction-lubrication mechanism prevailing in articular cartilage: A hypothesis. Tribol. Lett. 2008, 30, 83-90. open in new tab
  41. Bełdowski, P.; Winkler, R.G.; Augé, W.K.; Hładyszowski, J.; Gadomski, A. Micelle confined in aqueous environment: Lubrication at the nanoscale and its nonlinear characteristics. In Dynamical Systems: Modelling; open in new tab
  42. Springer Proceedings in Mathematics and Statistics; Springer International Publishing AG: Cham, Switzerland, 2016; pp. 73-80, ISBN 978-3-319-42401-9. open in new tab
  43. Bełdowski, P.; Augé, W.K.; Gadomski, A. Nanoscale friction requirements for the boundary lubrication behavior of model articular systems. In Current Topics in Quantum Biology; Michalak, K., Nawrocka-Bogusz, H., Eds.; Publishing House of Adam Mickiewicz University of Poznań: Poznań, Poland, 2014; pp. 79-93, ISBN 978-83-232-2775-5.
  44. Gadomski, A.; Bełdowski, P.; Rubi, J.M.; Urbaniak, W.; Augé, W.K.; Santamaria-Holek, I.; Pawlak, Z. Some conceptual thoughts toward nanoscale oriented friction in a model of articular cartilage. Math. Biosci. 2013, 244, 188-200. open in new tab
  45. Seror, J.; Zhu, L.; Goldberg, R.; Day, A.J.; Klein, J. Supramolecular synergy in the boundary lubrication of synovial joints. Nat. Commun. 2015, 6, 6497. open in new tab
  46. Bonnevie, E.D.; Delco, M.L.; Jasty, N.; Bartell, L.; Fortier, L.A.; Cohen, I.; Bonassar, L.J. Chondrocyte death and mitochondrial dysfunction are mediated by cartilage friction and shear strain. Ostheoarthr. Cartil. 2016, 24, S46. open in new tab
  47. Connoly, M.L. Analytical molecular surface calculation. J. Appl. Cryst. 1983, 16, 548-558. open in new tab
  48. Richmond, T.J. Solvent accessible surface area and excluded volume in proteins. Analytical equations for overlapping spheres and implications for the hydrophobic effect. J. Mol. Biol. 1984, 178, 63-89. c 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). open in new tab
Verified by:
Gdańsk University of Technology

seen 114 times

Recommended for you

Meta Tags