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Abstract
Two non-platinum compounds, organometallic half-sandwich complexes [(η 5 -Cp)IrCl(L)]PF 6 (1) and [(η 5 -Cp)RhCl(L)]PF 6 (2) were prepared by treating pentamethylcyclopentadienyl chloride dimers of iridium(III) or rhodium(III) with the obtained 4-amino-N-(2,2'-bipyridin-5- yl)benzenesulfonamide ligand (L) and ammonium hexafluorophosphate. The crystal structures of ligand (L) and complexes 1 and 2 were obtained and then analyzed. Coordination reactions of the bipyridylsufonamide ligand (L) to the central ions were confirmed by UV- Vis, FT-IR, NMR ( 1 H, 13 C, and 15 N) spectroscopies, and stability study. Moreover, the interactions between the sulfaligand, Ir(III) and Rh(III) complexes with carbonic anhydrase (CA), human serum albumin (HSA) and also with CT-DNA have been investigated. Additionally, the reactivity of complexes toward GSH and NADH has been spectrophotometrically tested. A low affinity of complex 2 to GSH seems to be beneficial regarding its potential cytotoxic activity. The obtained compounds were then evaluated for their antiproliferative activity against four cancer cell lines from different origins: non-small cell lung cancer A549, colon cancer HCT-116, breast cancer MCF7, lymphoblastic leukemia Nalm-6, and a nonmalignant human embryonic kidney cell line HEK293. It has been observed that the iridium(III) complex (1) was found to exhibit a lack of antiproliferative properties against the tested cancer cell lines. The sulfonamide ligand (L) and the rhodium(III) complex (2) were studied in detail for colon cancer HCT-116 cell line, and the detailed biological analysis was reported and discussed.
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Authors (9)
-
Mateusz Kowalik mgr
-
Joanna Masternak dr
-
Jerzy Sitkowski
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Aleksandra Dąbrowska
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Agnieszka Chylewska
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Mariusz Makowski
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
INORGANIC CHEMISTRY
no. 63,
pages 1296 - 1316,
ISSN: 0020-1669 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Kowalik M., Masternak J., Olszewski M., Maciejewska N., Kazimierczuk K., Sitkowski J., Dąbrowska A., Chylewska A., Makowski M.: Anticancer Study on IrIII and RhIII Half-Sandwich Complexes with the Bipyridylsulfonamide Ligand// INORGANIC CHEMISTRY -Vol. 63,iss. 2 (2024), s.1296-1316
- DOI:
- Digital Object Identifier (open in new tab) 10.1021/acs.inorgchem.3c038010000
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
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