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Abstract
Several classes of compounds are applied in clinics due to their immunosuppressive properties in transplantology and the treatment of autoimmune diseases. Derivatives of mycophe-nolic acid, corticosteroids and chemotherapeutics bearing heterocyclic moieties like methotrexate, azathioprine, mizoribine, and ruxolitinib are active substances with investigated mechanisms of action. However, improved synthetic approaches of known drugs and novel derivatives are still being reported to attempt better accessibility and therapeutic properties. In this review article, we present the synthesis of the designed chemical structures based on recent literature reports con-cerning novel compounds as promising immunosuppressive drugs. Moreover, some of the dis-cussed derivers revealed also other types of activities with prospective medicinal potential.
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Authors (3)
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Dorota Iwaszkiewicz-Grześ Dr
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
CURRENT TOPICS IN MEDICINAL CHEMISTRY
no. 24,
pages 1230 - 1263,
ISSN: 1568-0266 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Walczak J., Iwaszkiewicz-Grześ D., Cholewiński G.: Approaches Towards Better Immunosuppressive Agents// CURRENT TOPICS IN MEDICINAL CHEMISTRY -Vol. 24,iss. 14 (2024), s.1230-1263
- DOI:
- Digital Object Identifier (open in new tab) 10.2174/0115680266292661240322072908
- Sources of funding:
-
- Statutory activity/subsidy
- Verified by:
- Gdańsk University of Technology
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