Development of an orbital shaker-assisted fatty acid-based switchable solvent microextraction procedure for rapid and green extraction of amoxicillin from complex matrices: Central composite design - Publication - Bridge of Knowledge

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Development of an orbital shaker-assisted fatty acid-based switchable solvent microextraction procedure for rapid and green extraction of amoxicillin from complex matrices: Central composite design

Abstract

In this study, a cheap, fast and simple orbital shaker-assisted fatty acid-based switchable solvent microextraction (OS-FASS-ME) procedure was developed for the extraction of amoxicillin (AMOX) in dairy products, pharmaceutical samples and wastewater prior to its spectrophotometric analysis. Fatty acid-based switchable solvents were investigated for extracting AMOX. The key factors of the OS-FASS-ME procedure were optimized using a central composite design. The linearity of OS-FASS-ME procedure was in the range 5–600 ng mL−1 with a correlation coefficient of 0.991. In five replicate experiments for 20 ng mL−1 of AMOX solution, the recovery and relative standard deviation were 95.8% and 2.2%, respectively. Limits of detection and quantification were found 1.5 ng mL−1 and 5 ng mL−1, respectively. The accuracy, precision, robustness and selectivity of the OS-FASS-ME procedure were investigated in detail under optimum conditions. The OS-FASS-ME procedure was applied to milk, cheese, wastewater, syrups and tablets. A comparison of the results obtained from the reference method and the OS-FASS-ME method showed that the OS-FASS-ME procedure can be successfully applied to complex matrices.

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
FOOD CHEMISTRY no. 454,
ISSN: 0308-8146
Language:
English
Publication year:
2024
Bibliographic description:
Elik A., Demirkol Y., Ul Haq H., Boczkaj G., Sanaullah K., Altunay N.: Development of an orbital shaker-assisted fatty acid-based switchable solvent microextraction procedure for rapid and green extraction of amoxicillin from complex matrices: Central composite design// FOOD CHEMISTRY -Vol. 454, (2024), s.139785-
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.foodchem.2024.139785
Sources of funding:
  • COST_FREE
Verified by:
Gdańsk University of Technology

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