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Efficient synthesis and antifungal investigation of nucleosides’ quaternary ammonium salt derivatives

Abstract

Quaternary ammonium salts are a group of compounds with diverse biological properties, the most important of which are their antiviral, antibacterial, and antifungal activities. The quaternization reactions of 5'-O-tosyl derivatives of uridine and thymidine with triethylamine, trimethylamine, 4-(N ,N -dimethylamino)pyridine, 2-methylpyridine, and pyridine are described in this article. Two of the synthesized compounds are exceptional because they are first of this type that demonstrate concentration-dependent antifungal in vitro activity against two species of the genus Candida in minimal YNB-SG medium. The experimental results have been extended by adding full atom molecular dynamics simulations and substrates and products energies evaluation.

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Details

Category:
Magazine publication
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
TURKISH JOURNAL OF CHEMISTRY no. 43, pages 157 - 171,
ISSN: 1300-0527
Language:
English
Publication year:
2019
Bibliographic description:
Dmochowska B., Pellowska-Januszek L., Samaszko J., Ślusarz R., Wakieć R., Madaj J.: Efficient synthesis and antifungal investigation of nucleosides’ quaternary ammonium salt derivatives// TURKISH JOURNAL OF CHEMISTRY. -Vol. 43, (2019), s.157-171
DOI:
Digital Object Identifier (open in new tab) 10.3906/kim-1808-34
Verification:
Gdańsk University of Technology

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