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Abstract
Aims We aimed to identify the pivotal differences in the DNA methylation profiles between the regeneration capable MRL/MpJ mouse and reference mouse strains. Materials and Methods Global DNA methylation profiling was performed in ear pinnae, bone marrow, spleen, liver, heart from uninjured adult females of the MRL/MpJ and C57BL/6J and BALB/c. Results and conclusion A number of differentially methylated regions distinguishing between the MRL/MpJ mouse and both references were identified. In the ear pinnae, the differentially methylated regions were enriched in genes associated with development, inflammation and apoptosis, and in binding sites of transcriptional modulator Smad1. Several differentially methylated regions overlapped previously mapped quantitative trait loci of regenerative capability. The results suggest a potential epigenetic determinants of regenerative phenomenon
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Authors (4)
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Anna Ronowicz
- GUM
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Piotr Madanecki
- GUM
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.2217/epi-2017-0009
- License
- Copyright (2017 Future Medicine Ltd)
Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
EPIGENOMICS-UK
no. 9,
pages 1105 - 1122,
ISSN: 1750-1911 - Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Górnikiewicz B., Ronowicz A., Madanecki P., Sachadyn P.: Genome-wide DNA methylation profiling of the regenerative MRL/MpJ mouse and two normal strains// EPIGENOMICS-UK. -Vol. 9, nr. 8 (2017), s.1105-1122
- DOI:
- Digital Object Identifier (open in new tab) 10.2217/epi-2017-0009
- Verified by:
- Gdańsk University of Technology
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