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Immune escape of B-cell lymphoblastic leukemic cells through a lineage switch to acute myeloid leukemia
Abstract
Acute leukemia (AL) with a lineage switch (LS) is associated with poor prognosis. The predisposing factors of LS are unknown, apart from KMT2A rearrangements that have been reported to be associated with LS. Herein, we present two cases and review all 104 published cases to identify risk factors for LS. Most of the patients (75.5%) experienced a switch from the lymphoid phenotype to the myeloid phenotype. Eighteen patients (17.0%) experienced a transformation from acute myelogenous leukemia (AML) to acute lymphoblastic leukemia (ALL). Forty-nine (46.2%) patients carried a KMT2A rearrangement. Most of the cases involved LS from B-cell ALL (B-ALL) to AML (59.4%), and 49 patients (46.2%) carried KMT2A-rearrangements. Forty patients (37.7%) received lineage-specific immunotherapy. Our findings suggest that the prevalence of KMT2A rearrangements together with the lineage-specific immunotherapy may trigger LS, which supports the thesis of the existence of leukemia stem cells that are capable of lymphoid or myeloid differentiation.
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Authors (7)
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Karolina Bełdzińska-Gądek
- GUMed
-
Ewa Zarzycka
- GUMed
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Katarzyna Borman
- Intercollegiate Biotechnology Doctoral School, University of Gdańsk and Medical University of Gdańsk
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Krzysztof Lewandowski
- GUMed
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Jan M. Zaucha
- UCK Gdańsk
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Witold Prejzner
- GUMed
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
LEUKEMIA & LYMPHOMA
no. 65,
pages 1292 - 1302,
ISSN: 1042-8194 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Bełdzińska-Gądek K., Zarzycka E., Pastuszak K., Borman K., Lewandowski K., Zaucha J. M., Prejzner W.: Immune escape of B-cell lymphoblastic leukemic cells through a lineage switch to acute myeloid leukemia// LEUKEMIA & LYMPHOMA -Vol. 65,iss. 9 (2024), s.1292-1302
- DOI:
- Digital Object Identifier (open in new tab) 10.1080/10428194.2024.2351194
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
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