Search
Abstract
The mammalian heart is thought to be incapable of regeneration because of the limited ability of cardiomyocytes. to proliferate. However, it has been recently shown that the neonatal murine heart is able to restore its normal function after coronary artery ligation or even partial resection. Unfortunately, this feature is lost in a few days after birth, although lower vertebrates as zebrafish or newt, retain this ability until adulthood. Therefore, the mammalian cardiomyocyte withdraw from the cell cycle seems to be the biggest barrier for the regeneration in adult organisms. Hence, the analysis of the mechanisms that guide this transition in the neonatal life may be employed to awake the dormant regenerative potential of the heart. In this paper the recent findings on the neonatal heart regeneration have been presented.
Cite as
Full text
full text is not available in portal
Keywords
Details
- Category:
- Monographic publication
- Type:
- rozdział, artykuł w książce - dziele zbiorowym /podręczniku w języku o zasięgu międzynarodowym
- Title of issue:
- PhD Interdisciplinary Journal. - No. 2 strony 127 - 130
- Language:
- English
- Publication year:
- 2013
- Bibliographic description:
- Górnikiewicz B., Podolak-Popinigis J.: Insight into heart regeneration// PhD Interdisciplinary Journal. - No. 2/ ed. M. Czubenko : GUT, 2013, s.127-130
- Verified by:
- Gdańsk University of Technology
seen 99 times
Recommended for you
Transcriptomic responses to wounding: meta-analysis of gene expression microarray data
- P. Sass,
- M. Dąbrowski,
- A. Charzyńska
- + 1 authors
Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing
- A. Kur-Piotrowska,
- M. Kopcewicz,
- L. Kozak
- + 3 authors