Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing

Anna Kur-Piotrowska; Marta Kopcewicz; Leslie Kozak; Paweł Sachadyn; Anna Grabowska; Barbara Gawronska-Kozak

doi:10.1186/s12864-016-3401-z

Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing

Abstract

Mouse fetuses up to 16 day of embryonic development and nude (Foxn1- deficient) mice are examples of animals that undergo regenerative (scar-free) skin healing. The expression of transcription factor Foxn1 in the epidermis of mouse fetuses begins at embryonic day 16.5 which coincides with the transition point from scar-free to scar-forming skin wound healing. In the present study, we tested the hypothesis that Foxn1 expression in the skin is an essential condition to establish the adult skin phenotype and that Foxn1 inactivity in nude mice keeps skin in the immature stage resembling the phenomena of neoteny.

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Authors (6)

Anna Kur-Piotrowska
- Instytut Rozrodu Zwierząt i Badań Żywności P.A.N
Marta Kopcewicz
- Instytut Rozrodu Zwierząt i Badań Żywności P.A.N
Leslie Kozak
- Instytut Rozrodu Zwierząt i Badań Żywności P.A.N
Paweł Sachadyn prof. dr hab. inż.
Anna Grabowska
- Instytut Rozrodu Zwierząt i Badań Żywności P.A.N
Barbara Gawronska-Kozak
- Instytut Rozrodu Zwierząt i Badań Żywności P.A.N

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Keywords

TRANSCRIPTOME NEXT-GENERATION SEQUENCING REGENERATION MMP-9

Details

Category:: Articles
Type:: artykuł w czasopiśmie wyróżnionym w JCR
Published in:: BMC GENOMICS no. 18, pages 1 - 15,
ISSN: 1471-2164
Language:: English
Publication year:: 2017
Bibliographic description:: Kur-Piotrowska A., Kopcewicz M., Kozak L., Sachadyn P., Grabowska A., Gawronska-Kozak B.: Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing// BMC GENOMICS. -Vol. 18, (2017), s.1-15
DOI:: Digital Object Identifier (open in new tab) 10.1186/s12864-016-3401-z
Verified by:: Gdańsk University of Technology