Long-term mortality after transcatheter aortic valve implantation for aortic stenosis in immunosuppression-treated patients: a propensity-matched multicentre retrospective registry-based analysis - Publication - Bridge of Knowledge

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Long-term mortality after transcatheter aortic valve implantation for aortic stenosis in immunosuppression-treated patients: a propensity-matched multicentre retrospective registry-based analysis

Abstract

Introduction Data regarding patients with a previous medical record of immunosuppression treatment who have undergone transcatheter aortic valve implantation (TAVI) are limited and extremely inconclusive. Available studies are mostly short term observations; thus there is a lack of evidence on efficacy and safety of TAVI in this specific group of patients. Aim To compare the in-hospital and long-term outcomes between patients with or without a medical history of immunosuppressive treatment undergoing TAVI for aortic valve stenosis (AS). Material and methods We conducted a retrospective registry-based analysis including patients undergoing TAVI for AS at 5 centres between January 2009 and August 2017. The primary endpoint was long-term all-cause mortality. Secondary endpoints comprised major vascular complications, life-threatening or disabling bleeding, stroke and new pacemaker implantation. Results Of 1451 consecutive patients who underwent TAVI, two propensity-matched groups including 25 patients with a history of immunosuppression and 75 patients without it were analysed. No differences between groups in all-cause mortality were found in a median follow-up time of 2.7 years following TAVI (p = 0.465; HR = 0.73; 95% CI: 0.30–1.77). The rate of major vascular complications (4.0% vs. 5.3%) was similar in the two groups (p = 1.000). There were no statistically significant differences in the composite endpoint combining life-threatening or disabling bleeding, major vascular complications, stroke and new pacemaker implantation (40.0% vs. 20.0%, p = 0.218). Conclusions Patients who had undergone TAVI for AS had similar long-term mortality regardless of whether they had a previous medical record of immunosuppression. Procedural complication rates were comparable between the groups.

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DOI:
Digital Object Identifier (open in new tab) 10.5114/aic.2023.131478
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Category:
Articles
Type:
artykuły w czasopismach
Published in:
Postępy w Kardiologii Interwencyjnej no. 19, pages 251 - 256,
ISSN: 1734-9338
Language:
English
Publication year:
2023
Bibliographic description:
Walczewski M., Gąsecka A., Witkowski A., Dabrowski M., Huczek Z., Wilimski R., Ochała A., Parma R., Rymuza B., Grygier M., Jemielity M., Olasińska-Wiśniewska A., Jagielak D., Targoński R., Pastuszak K., Gresner P., Grabowski M., Kochman J.: Long-term mortality after transcatheter aortic valve implantation for aortic stenosis in immunosuppression-treated patients: a propensity-matched multicentre retrospective registry-based analysis// Postępy w Kardiologii Interwencyjnej -Vol. 19,iss. 3 (2023), s.251-256
DOI:
Digital Object Identifier (open in new tab) 10.5114/aic.2023.131478
Sources of funding:
  • Spoza PG
Verified by:
Gdańsk University of Technology

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