Long-term mortality after transcatheter aortic valve implantation for aortic stenosis in immunosuppression-treated patients: a propensity-matched multicentre retrospective registry-based analysis - Publication - Bridge of Knowledge

Your account

login

Search

Long-term mortality after transcatheter aortic valve implantation for aortic stenosis in immunosuppression-treated patients: a propensity-matched multicentre retrospective registry-based analysis

Abstract

Introduction Data regarding patients with a previous medical record of immunosuppression treatment who have undergone transcatheter aortic valve implantation (TAVI) are limited and extremely inconclusive. Available studies are mostly short term observations; thus there is a lack of evidence on efficacy and safety of TAVI in this specific group of patients. Aim To compare the in-hospital and long-term outcomes between patients with or without a medical history of immunosuppressive treatment undergoing TAVI for aortic valve stenosis (AS). Material and methods We conducted a retrospective registry-based analysis including patients undergoing TAVI for AS at 5 centres between January 2009 and August 2017. The primary endpoint was long-term all-cause mortality. Secondary endpoints comprised major vascular complications, life-threatening or disabling bleeding, stroke and new pacemaker implantation. Results Of 1451 consecutive patients who underwent TAVI, two propensity-matched groups including 25 patients with a history of immunosuppression and 75 patients without it were analysed. No differences between groups in all-cause mortality were found in a median follow-up time of 2.7 years following TAVI (p = 0.465; HR = 0.73; 95% CI: 0.30–1.77). The rate of major vascular complications (4.0% vs. 5.3%) was similar in the two groups (p = 1.000). There were no statistically significant differences in the composite endpoint combining life-threatening or disabling bleeding, major vascular complications, stroke and new pacemaker implantation (40.0% vs. 20.0%, p = 0.218). Conclusions Patients who had undergone TAVI for AS had similar long-term mortality regardless of whether they had a previous medical record of immunosuppression. Procedural complication rates were comparable between the groups.

Citations

  • 0

    CrossRef

  • 0

    Web of Science

  • 0

    Scopus

Authors (18)

Cite as

Full text

download paper
downloaded 2 times
Publication version
Accepted or Published Version
DOI:
Digital Object Identifier (open in new tab) 10.5114/aic.2023.131478
License
Creative Commons: CC-BY-NC-SA open in new tab

Keywords

Details

Category:
Articles
Type:
artykuły w czasopismach
Published in:
Postępy w Kardiologii Interwencyjnej no. 19, pages 251 - 256,
ISSN: 1734-9338
Language:
English
Publication year:
2023
Bibliographic description:
Walczewski M., Gąsecka A., Witkowski A., Dabrowski M., Huczek Z., Wilimski R., Ochała A., Parma R., Rymuza B., Grygier M., Jemielity M., Olasińska-Wiśniewska A., Jagielak D., Targoński R., Pastuszak K., Gresner P., Grabowski M., Kochman J.: Long-term mortality after transcatheter aortic valve implantation for aortic stenosis in immunosuppression-treated patients: a propensity-matched multicentre retrospective registry-based analysis// Postępy w Kardiologii Interwencyjnej -Vol. 19,iss. 3 (2023), s.251-256
DOI:
Digital Object Identifier (open in new tab) 10.5114/aic.2023.131478
Sources of funding:
  • Spoza PG
Verified by:
Gdańsk University of Technology

seen 28 times

Recommended for you

Fluid–Structure Interaction methods for the progressive anatomical and artificial aortic valve stenosis

2022

Physiological Biomarkers Assessed by Low‐Tech Exercise Tests Predict Complications and Overall Survival in Patients Undergoing Pneumonectomy Due to Lung Cancer

  • T. Marjanski,
  • D. Wnuk,
  • R. Dziedzic
  • + 4 authors
2021

Multiscale model for blood flow after a bileaflet artificial aortic valve implantation

2023

Late Aortic Remodeling after Endovascular Repair of Complicated Type B Aortic Dissection—TEVAR Protects Only the Covered Segment of Thoracic Aorta

2019
Meta Tags