Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations

Paulina Kaźmierska-Grębowska; Maciej Jankowski; Bruce M. MacIver

doi:10.14336/ad.2023.0607

Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations

Abstract

Increasing evidence indicates a role of hyperpolarization activated cation (HCN) channels in controlling the resting membrane potential, pacemaker activity, memory formation, sleep, and arousal. Their disfunction may be associated with the development of epilepsy and age-related memory decline. Neuronal hyperexcitability involved in epileptogenesis and EEG desynchronization occur in the course of dementia in human Alzheimer’s Disease (AD) and animal models, nevertheless the underlying ionic and cellular mechanisms of these effects are not well understood. Some suggest that theta rhythms involved in memory formation could be used as a marker of memory disturbances in the course of neurogenerative diseases, including AD. This review focusses on the interplay between hyperpolarization HCN channels, theta oscillations, memory formation and their role(s) in dementias, including AD. While individually, each of these factors have been linked to each other with strong supportive evidence, we hope here to expand this linkage to a more inclusive picture. Thus, HCN channels could provide a molecular target for developing new therapeutic agents for preventing and/or treating dementia.

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Authors (3)

Paulina Kaźmierska-Grębowska dr
- Department of Neurobiology, Faculty of Biology and Environmental Protection, University of Lodz, Poland.
Maciej Jankowski dr
Bruce M. MacIver PhD
- Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of of Medicine, Stanford University, CA, USA.

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Keywords

ALZHEIMER'S DISEASE, DEMENTIA, LAMOTRIGINE, HCN CHANNELS, IH CURRENT, THETA OSCILLATIONS, MEMORY, EEG

Details

Category:

Articles

Type:

artykuły w czasopismach

Published in:

Aging and Disease no. 15, pages 22 - 42,
ISSN: 2152-5250

Language:

English

Publication year:

2024

Bibliographic description:

Kaźmierska-Grębowska P., Jankowski M., Maciver B. M.: Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations// Aging and Disease -Vol. 15,iss. 1 (2024), s.22-42

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