Plasma free amino acid profiling as metabolomic diagnostic and prognostic biomarker in paediatric cancer patients: a follow‑up study - Publication - Bridge of Knowledge

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Plasma free amino acid profiling as metabolomic diagnostic and prognostic biomarker in paediatric cancer patients: a follow‑up study

Abstract

Amino acids (AAs) play a crucial role in cancer cell metabolism. Levels of 22 plasma AAs at the time of diagnosis and after treatment were established among 39 pediatric cancer patients and 33 healthy children. Glutamic acid levels decreased and tryptophan levels increased during treatment. Cancer patients presented significantly lower levels of glutamine and leucine post-treatment while levels of 12 other AAs were higher comparing to controls. Results suggest that plasma free AA profile may serve as a prognostic biomarker.

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Authors (9)

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
AMINO ACIDS no. 53, pages 133 - 138,
ISSN: 0939-4451
Language:
English
Publication year:
2021
Bibliographic description:
Synakiewicz A., Stanisławska-Sachadyn A., Sawicka-Żukowska M., Gałęzowska G., Ratajczyk J., Owczarzak A., Skuza M., Wolska L., Stachowicz-Stencel T.: Plasma free amino acid profiling as metabolomic diagnostic and prognostic biomarker in paediatric cancer patients: a follow‑up study// AMINO ACIDS -Vol. 53, (2021), s.133-138
DOI:
Digital Object Identifier (open in new tab) 10.1007/s00726-020-02910-8
Verified by:
Gdańsk University of Technology

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