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Plasma free amino acid profiling as metabolomic diagnostic and prognostic biomarker in paediatric cancer patients: a follow‑up study
Abstract
Amino acids (AAs) play a crucial role in cancer cell metabolism. Levels of 22 plasma AAs at the time of diagnosis and after treatment were established among 39 pediatric cancer patients and 33 healthy children. Glutamic acid levels decreased and tryptophan levels increased during treatment. Cancer patients presented significantly lower levels of glutamine and leucine post-treatment while levels of 12 other AAs were higher comparing to controls. Results suggest that plasma free AA profile may serve as a prognostic biomarker.
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Authors (9)
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Anna Synakiewicz Dr
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Małgorzata Sawicka-Żukowska Dr n. med.
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Grażyna Gałęzowska
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Joanna Ratajczyk dr
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Anna Owczarzak dr
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Małgorzata Skuza
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Lidia Wolska
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Teresa Stachowicz-Stencel dr. hab.
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- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1007/s00726-020-02910-8
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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AMINO ACIDS
no. 53,
pages 133 - 138,
ISSN: 0939-4451 - Language:
- English
- Publication year:
- 2021
- Bibliographic description:
- Synakiewicz A., Stanisławska-Sachadyn A., Sawicka-Żukowska M., Gałęzowska G., Ratajczyk J., Owczarzak A., Skuza M., Wolska L., Stachowicz-Stencel T.: Plasma free amino acid profiling as metabolomic diagnostic and prognostic biomarker in paediatric cancer patients: a follow‑up study// AMINO ACIDS -Vol. 53, (2021), s.133-138
- DOI:
- Digital Object Identifier (open in new tab) 10.1007/s00726-020-02910-8
- Verified by:
- Gdańsk University of Technology
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