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Abstract
Introduction: Recent years, microbiota-associated aspects have been analysed in multiple disorders regarding cancers. Existing evidence pints that gut microorganisms might take part in tumour origin and therapy efficacy. Nevertheless, to date, data on faecal metabolomics in cancer patients is still strongly limited. Therefore, we aimed to analyse gut untargeted metabolome in gastrointestinal cancer patients (i.e., gastric and colorectal cancer). Patients and methods: There were 12 patients with either gastric (n=4) or colorectal cancer (n=8) enrolled and 8 analysed (n=4 each). Stool samples were collected prior to anti-cancer treatments. Untargeted metabolomics analyses were conducted by means of mass spectrometry. Results: A plethora of metabolites in cancer patients we analysed were noted, with higher homogenity in case of gastric cancer patients. We found that the level of Deoxyguanosine,m/z 266.091,[M-H]-, Uridine,m/z 245.075,[M+H]+, Deoxyguanosine,m/z 268.104,[M]+, 3-Indoleacetic acid,m/z 176.07,[M+H]+, Indoxyl,m/z 132.031,[M-H]-, L-Phenylalanine,m/z 164.073,[M-H]-, L-Methionine, m/z 150.058,[M+NH4]+, was significantly higher in colorectal cancer patients and Ethyl hydrogen malonate,m/z 133.031,[M+H]+ in gastric cancer. Conclusion: The overall insights into untargeted metabolomics showed that most often higher levels of analysed metabolites were detected in colorectal cancer patients compared to gastric cancer patients. The link between gut metabolome and both local and distal metastasis might exist, however it requires confirmation in further multi-centre studies regarding larger sample size.
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Authors (10)
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Karolina Kaźmierczak-Siedlecka
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Damian Muszyński
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Daniel Styburski
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Jakub Makarewicz
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Bartosz Kamil Sobocki
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Paweł Ulasiński
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Karol Połom
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Ewa Stachowska
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Karolina Skonieczna-Żydecka
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.3389/fcimb.2024.1394038
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
no. 14,
pages 1 - 10,
ISSN: 2235-2988 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Kaźmierczak-Siedlecka K., Muszyński D., Styburski D., Makarewicz J., Sobocki B. K., Ulasiński P., Połom K., Stachowska E., Skonieczna-Żydecka K., Kalinowski L.: Untargeted metabolomics in gastric and colorectal cancer patients – preliminary results// FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY -Vol. 14, (2024),
- DOI:
- Digital Object Identifier (open in new tab) 10.3389/fcimb.2024.1394038
- Sources of funding:
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- This study has been funded by MTN grant from the Medical University of Gdansk, Poland (KK-S; grant no: 71-01213), and from the Ministry of Science and Higher Education, Poland (grant no. 2/566516/ SPUB/SP/2023).
- Verified by:
- Gdańsk University of Technology
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