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Abstract
Designing biomaterials capable of biomimicking wound healing and skin regeneration has been receiving increasing attention recently. Some biopolymers behave similarly to the extracellular matrix (ECM), supporting biointerfacial adhesion and intrinsic cellular interactions. Polydopamine (PDA) is a natural bioadhesive and bioactive polymer that endows high chemical versatility, making it an exciting candidate for a wide range of biomedical applications. Moreover, biomaterials based on PDA and its derivatives have near-infrared (NIR) absorption, excellent biocompatibility, intrinsic antioxidative activity, antibacterial activity, and cell affinity. PDA can regulate cell behavior by controlling signal transduction pathways. It governs the focal adhesion behavior of cells at the biomaterials interface. These features make melanin-like PDA a fascinating biomaterial for wound healing and skin regeneration. This paper overviews PDA-based biomaterials’ synthesis, properties, and interactions with biological entities. Furthermore, the utilization of PDA nano- and microstructures as a constituent of wound-dressing formulations is highlighted.
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Authors (9)
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Mohsen Khodadadi Yazdi
-
Mehrak Zare
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Ali Khodadadi
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Farzad Seidi
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S. Mohammad Sajadi
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Payam Zarrintaj
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Ahmad Arefi
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Masoud Mozafari
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
ACS Biomaterials Science & Engineering
no. 8,
pages 2196 - 2219,
ISSN: 2373-9878 - Language:
- English
- Publication year:
- 2022
- Bibliographic description:
- Yazdi M. K., Zare M., Khodadadi A., Seidi F., Sajadi S. M., Zarrintaj P., Arefi A., Saeb M., Mozafari M.: Polydopamine Biomaterials for Skin Regeneration// ACS Biomaterials Science & Engineering -Vol. 8,iss. 6 (2022), s.2196-2219
- DOI:
- Digital Object Identifier (open in new tab) 10.1021/acsbiomaterials.1c01436
- Sources of funding:
-
- COST_FREE
- Verified by:
- Gdańsk University of Technology
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