Procognitive activity of nitric oxide inhibitors and donors in animal models

Paulina Cieślik; Leszek Kalinowski; Joanna M. Wierońska

doi:10.1016/j.niox.2021.12.003

Procognitive activity of nitric oxide inhibitors and donors in animal models

Abstract

Nitric oxide is a small gaseous molecule that plays important roles in the majority of biological functions. Impairments of NO-related pathways contribute to the majority of neurological disorders, such as Alzheimer’s disease (AD), and mental disorders, such as schizophrenia. Cognitive decline is one of the most serious impairments accompanying both AD and schizophrenia. In the present study, the activities of NO donors, slow (spermine NONOate) or fast (DETANONOate) releasers, and selective inhibitor of neuronal nitric oxide synthase N(ω)-propyl-L-arginine (NPLA) were investigated in pharmacological models of schizophrenia and AD. Cognitive impairments were induced by administration of MK- 801 or scopolamine and were measured in novel object recognition (NOR) and Y-maze tests. The compounds were investigated at doses of 0.05–0.5 mg/kg. The dose-dependent effectiveness of all the compounds was observed in the NOR test, while only the highest doses of spermine NONOate and NPLA were active in the Ymaze test. DETANONOate was not active in the Y-maze test. The impact of the investigated compounds on motor coordination was tested at doses of 0.5 and 1 mg/kg. Only NPLA at a dose of 1 mg/kg slightly disturbed motor coordination in animals.

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Keywords

SPERMINE NONOATE DETANONOATE NPLA SCHIZOPHRENIA ALZHEIMER'S DISEASE COGNITION

Details

Category:

Articles

Type:

artykuły w czasopismach

Published in:

NITRIC OXIDE-BIOLOGY AND CHEMISTRY no. 119, pages 29 - 40,
ISSN: 1089-8603

Language:

English

Publication year:

2022

Bibliographic description:

Cieślik P., Kalinowski L., Wierońska J. M.: Procognitive activity of nitric oxide inhibitors and donors in animal models// NITRIC OXIDE-BIOLOGY AND CHEMISTRY -Vol. 119, (2022), s.29-40

DOI: